TY - JOUR T1 - Negative CT Angiography Findings in Patients with Spontaneous Subarachnoid Hemorrhage: When Is Digital Subtraction Angiography Still Needed? JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 696 LP - 705 DO - 10.3174/ajnr.A1884 VL - 31 IS - 4 AU - R. Agid AU - T. Andersson AU - H. Almqvist AU - R.A. Willinsky AU - S.-K. Lee AU - K.G. terBrugge AU - R.I. Farb AU - M. Söderman Y1 - 2010/04/01 UR - http://www.ajnr.org/content/31/4/696.abstract N2 - BACKGROUND AND PURPOSE: CTA is becoming the frontline modality to reveal aneurysms in patients with SAH. However, in about 20% of SAH patients no aneurysm is found. In these cases, intra-arterial DSA is still performed. Our aim was to evaluate whether negative findings on CTA can reliably exclude aneurysms in patients with acute SAH. MATERIALS AND METHODS: We conducted a retrospective analysis of all negative findings on CTAs performed from 2005 to 2009 in patients with spontaneous SAH. Findings were compared with DSA. CTAs were performed with a 64-section multidetector row CT scanner. RESULTS: One hundred ninety-three patients with SAH and negative findings on CTA who underwent subsequent DSA were identified. The distribution of blood on unenhanced CT was the following: PMH in 93 patients, diffuse aneurysmal pattern in 50, no blood on CT (xanthochromic LP) in 32, and peripheral sulcal distribution in 18. All patients with PMH had negative findings on DSA. One patient with no blood on CT had vasculitis on DSA. Six of 18 (33%) patients with peripheral blood had vasculitis on DSA. Three of these were also diagnosed by CTA. All except 1 patient with diffuse aneurysmal blood had negative findings on DSA. One patient was diagnosed with an aneurysm on DSA (1/50, 0.5%). Repeat delayed DSA performed in 28 of these patients revealed a small aneurysm in 4 (14%). Five patients had a complication of DSA (2.6%); 1 was a clinical stroke (0.5%). CONCLUSIONS: In patients with SAH, negative CTA findings are reliable in ruling out aneurysms in the PMH pattern or no blood on CT. DSA is indicated in the diffuse aneurysmal pattern of SAH, and repeat delayed DSA is required if the initial DSA findings are negative. When the blood is peripheral, CTA should be scrutinized for vasculitis and DSA is recommended for confirmation. ACAanterior cerebral arteryAcomAanterior communicating arteryCIconfidence intervalCTACT angiographyDAVFdural arteriovenous fistulaDSAdigital subtraction angiographyGCSGlasgow Coma ScaleICAinternal carotid arteryLPlumbar punctureMIPmaximum intensity projectionMCAmiddle cerebral arteryMRAMR angiographyNPVnegative predictive valuePMHperimesencephalic hemorrhagePPVpositive predictive valueSAHsubarachnoid hemorrhage ER -