RT Journal Article
SR Electronic
T1 Hyperpolarized MR Imaging: Neurologic Applications of Hyperpolarized Metabolism
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 24
OP 33
DO 10.3174/ajnr.A1790
VO 31
IS 1
A1 B.D. Ross
A1 P. Bhattacharya
A1 S. Wagner
A1 T. Tran
A1 N. Sailasuta
YR 2010
UL http://www.ajnr.org/content/31/1/24.abstract
AB SUMMARY: Hyperpolarization is the general term for a method of enhancing the spin-polarization difference of populations of nuclei in a magnetic field. No less than 5 distinct techniques (dynamic nuclear polarization [DNP]; parahydrogen-induced polarization−parahydrogen and synthesis allow dramatically enhanced nuclear alignment [PHIP-PASADENA]; xenon/helium polarization transfer; Brute Force; 1H hyperpolarized water) are currently under exhaustive investigation as means of amplifying the intrinsically (a few parts per million) weak signal intensity used in conventional MR neuroimaging and spectroscopy. HD-MR imaging in vivo is a metabolic imaging tool causing much of the interest in HD-MR imaging. The most successful to date has been DNP, in which carbon-13 (13C) pyruvic acid has shown many. PHIP-PASADENA with 13C succinate has shown HD-MR metabolism in vivo in tumor-bearing mice of several types, entering the Krebs−tricarboxylic acid cycle for ultrafast detection with 13C MR imaging, MR spectroscopy, and chemical shift imaging. We will discuss 5 promising preclinical studies: 13C succinate PHIP in brain tumor; 13C ethylpyruvate DNP and 13C acetate; DNP in rodent brain; 13C succinate PHIP versus gadolinium imaging of stroke; and 1H hyperpolarized imaging. Recent developments in clinical 13C neurospectroscopy encourage us to overcome the remaining barriers to clinical HD-MR imaging.