TY - JOUR T1 - Apparent Diffusion and Fractional Anisotropy of Diffuse Intrinsic Brain Stem Gliomas JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1879 LP - 1885 DO - 10.3174/ajnr.A2179 VL - 31 IS - 10 AU - H.J. Chen AU - A. Panigrahy AU - G. Dhall AU - J.L. Finlay AU - M.D. Nelson, Jr. AU - S. Blüml Y1 - 2010/11/01 UR - http://www.ajnr.org/content/31/10/1879.abstract N2 - BACKGROUND AND PURPOSE: DIBSGs have the worst prognosis among pediatric brain tumors with no improvement of outcome for several decades. In this study, we determined whether diffusion imaging could improve patient stratification and our understanding of the impact of therapies. MATERIALS AND METHODS: Nine baseline and 24 follow-up DTI studies performed in 9 patients on a 1.5T clinical MR imaging scanner were reviewed. ADC and FA were measured for the whole lesion and at 5 anatomic levels: the rostral medulla, caudal pons, midpons, rostral pons, and caudal midbrain. Reference data were obtained from 8 controls with normal brain stem, 6 patients with medulloblastoma, and 7 patients with pilocytic astrocytoma. RESULTS: ADC was higher in untreated DIBSG than in normal brain stem and medulloblastoma (1.14 ± 0.18 [×10−3 mm2/s] versus 0.75 ± 0.06 and 0.56 ± 0.05, both P < .001). FA was lower in DIBSG than in normal brain stem (0.24 ± 0.04 versus 0.43 ± 0.02, P < .001) but was higher than that in pilocytic astrocytoma (0.17 ± 0.05, P < .05). Lower baseline ADC and higher FA correlated with a worse clinical course. Correlations were more significant at the caudal midbrain than in other regions. ADC decreased and FA increased after RT. Changes of FA after RT at the caudal midbrain correlated with event-free survival. CONCLUSIONS: Baseline ADC and FA of DIBSG revealed hypocellular tumors with extensive edema. Diffusion changes after therapy implied reduced edema but did not support a significant response to therapy. The significance of diffusion properties varied with anatomic locations, the caudal midbrain being particularly important. ADCapparent diffusion coefficientADCCMADC at the caudal midbrainADCLesionmean ADC of whole lesion calculated from the 5 anatomic regions examinedADCmaxlargest ADC value measured in the 5 anatomic regions examinedADCminlowest ADC value measured in the 5 anatomic regions examinedADCMPADC at the mid ponsADCRPADC at the rostral ponsAVAAvastin (bevacizumab)BslbaselineCPcarboplatinΔADCchange of ADC between the baseline study and the study immediately after completion of RTΔFAchange of FA between baseline study and study immediately after completion of RTΔTEFSevent-free survival after therapyΔTSurvivalsurvival time after diagnosisDIBSGdiffuse intrinsic brain stem gliomaDTIdiffusion tensor imagingETOetoposideFAfractional anisotropyFACMFA at the caudal midbrainFALesionmean FA of the whole lesion calculated from the 5 anatomic regions examinedFAmaxlargest FA value measured in the 5 anatomic regions examinedFAminlowest FA value measured in the 5 anatomic regions examinedGTgadolinium-texaphyrinIRIirinotecan (Camptosar)n.d.not determinedRTradiation therapyEarly post-RTwithin 3 months of completion of RTLate post-RT>3 months after completion of RTTEMtemozolomide (Temodar)WHOWorld Health Organization ER -