TY - JOUR T1 - Cerebral White Matter Lesions May Be Partially Reversible in Patients with Carotid Artery Stenosis JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1350 LP - 1352 DO - 10.3174/ajnr.A1873 VL - 31 IS - 7 AU - K. Yamada AU - K. Sakai AU - K. Owada AU - K. Mineura AU - T. Nishimura Y1 - 2010/08/01 UR - http://www.ajnr.org/content/31/7/1350.abstract N2 - SUMMARY: Contrary to the common belief that age-related WMLs (also known as leukoaraiosis) are a progressive condition, a case of partial reversal of WMLs shortly after carotid artery stenting is described. A 75-year-old man presented with frequent TIAs, which were attributed to right ICA stenosis. He subsequently underwent successful carotid artery stenting. Follow-up MR imaging a week after the procedure showed improvement of WMLs in the right cerebral hemisphere. Pixel-by-pixel image analysis showed that the reversed WMLs tended to have higher λ1 and lower signal intensity on b = 0 images compared with nonreversed lesions, but by only approximately 10%. ADCapparent diffusion coefficientBBBblood-brain barrierICAinternal carotid arteryDTIdiffusion tensor imagingDWIdiffusion-weighted imagingFLAIRfluid-attenuated inversion recoveryλ1axial diffusivityλ2 and λ3radial diffusivityMTTmean transit timeprebeforepostafterrCBFregional cerebral blood flowrCBVregional cerebral blood volumeTIAtransient ischemic attacksWMLwhite matter lesion ER -