PT  - JOURNAL ARTICLE
AU  - M. Tranfa
AU  - G. Pontillo
AU  - M. Petracca
AU  - A. Brunetti
AU  - E. Tedeschi
AU  - G. Palma
AU  - S. Cocozza
TI  - Quantitative MRI in Multiple Sclerosis: From Theory to Application
AID  - 10.3174/ajnr.A7536
DP  - 2022 Jun 09
TA  - American Journal of Neuroradiology
4099  - http://www.ajnr.org/content/early/2022/06/09/ajnr.A7536.short
4100  - http://www.ajnr.org/content/early/2022/06/09/ajnr.A7536.full
AB  - SUMMARY: Quantitative MR imaging techniques allow evaluating different aspects of brain microstructure, providing meaningful information about the pathophysiology of damage in CNS disorders. In the study of patients with MS, quantitative MR imaging techniques represent an invaluable tool for studying changes in myelin and iron content occurring in the context of inflammatory and neurodegenerative processes. In the first section of this review, we summarize the physics behind quantitative MR imaging, here defined as relaxometry and quantitative susceptibility mapping, and describe the neurobiological correlates of quantitative MR imaging findings. In the second section, we focus on quantitative MR imaging application in MS, reporting the main findings in both the gray and white matter compartments, separately addressing macroscopically damaged and normal-appearing parenchyma.bSSFPbalanced steady-state free precessionCLcortical lesionsGREgradient recalled-echoNAWMnormal-appearing white matterPDproton densityqMRIquantitative MR imagingQSMquantitative susceptibility mappingRFradiofrequency