PT  - JOURNAL ARTICLE
AU  - E.K. Embiruçu
AU  - M.C.G. Otaduy
AU  - A.K. Taneja
AU  - C.C. Leite
AU  - F. Kok
AU  - L.T. Lucato
TI  - MR Spectroscopy Detects Lipid Peaks in Cerebrotendinous Xanthomatosis
AID  - 10.3174/ajnr.A1885
DP  - 2010 Aug 01
TA  - American Journal of Neuroradiology
PG  - 1347--1349
VI  - 31
IP  - 7
4099  - http://www.ajnr.org/content/31/7/1347.short
4100  - http://www.ajnr.org/content/31/7/1347.full
SO  - Am. J. Neuroradiol.2010 Aug 01; 31
AB  - SUMMARY: CTX is a rare lipid-storage disease. Novel MRS findings from 3 patients, using a short TE, were the presence of lipid peaks at 0.9 and 1.3 ppm in the depth of the cerebellar hemisphere; this might represent an additional marker of disease that is CNS-specific and noninvasive. A decrease in NAA concentration was also detected and attributed to neuroaxonal damage. One patient presented an increase in mIns concentration, pointing to gliosis and astrocytic proliferation. a.u.arbitrary unitChocholine-containing compoundsCNScentral nervous systemCrcreatine/phosphocreatineCTXcerebrotendinous xanthomatosisLiplipidLip09lipid signals at 0.9 ppmLip13lipid signals at 1.3 ppmmInsmyo-inositolMRSMR spectroscopyNAAN-acetylaspartatePRESSpoint-resolved spectroscopy sequenceSTEAMshort echo time stimulated echo acquisition modeVOIvolume of interest