RT Journal Article
SR Electronic
T1 MR Spectroscopy Detects Lipid Peaks in Cerebrotendinous Xanthomatosis
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1347
OP 1349
DO 10.3174/ajnr.A1885
VO 31
IS 7
A1 E.K. Embiruçu
A1 M.C.G. Otaduy
A1 A.K. Taneja
A1 C.C. Leite
A1 F. Kok
A1 L.T. Lucato
YR 2010
UL http://www.ajnr.org/content/31/7/1347.abstract
AB SUMMARY: CTX is a rare lipid-storage disease. Novel MRS findings from 3 patients, using a short TE, were the presence of lipid peaks at 0.9 and 1.3 ppm in the depth of the cerebellar hemisphere; this might represent an additional marker of disease that is CNS-specific and noninvasive. A decrease in NAA concentration was also detected and attributed to neuroaxonal damage. One patient presented an increase in mIns concentration, pointing to gliosis and astrocytic proliferation. a.u.arbitrary unitChocholine-containing compoundsCNScentral nervous systemCrcreatine/phosphocreatineCTXcerebrotendinous xanthomatosisLiplipidLip09lipid signals at 0.9 ppmLip13lipid signals at 1.3 ppmmInsmyo-inositolMRSMR spectroscopyNAAN-acetylaspartatePRESSpoint-resolved spectroscopy sequenceSTEAMshort echo time stimulated echo acquisition modeVOIvolume of interest