TY - JOUR T1 - The Construction of a Predictive Composite Index for Decision-Making of CSF Diversion Surgery in Pediatric Patients following Prenatal Myelomeningocele Repair JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1214 LP - 1221 DO - 10.3174/ajnr.A7585 VL - 43 IS - 8 AU - F.T. Mangano AU - M. Altaye AU - C.B. Stevenson AU - W. Yuan Y1 - 2022/08/01 UR - http://www.ajnr.org/content/43/8/1214.abstract N2 - BACKGROUND AND PURPOSE: There is a wide range of clinical and radiographic factors affecting individual surgeons’ ultimate decision for CSF diversion for pediatric patients following prenatal myelomeningocele repair. Our aim was to construct a composite index (CSF diversion surgery index) that integrates conventional clinical measures and neuroimaging biomarkers to predict CSF diversion surgery in these pediatric patients.MATERIALS AND METHODS: This was a secondary retrospective analysis of data from 33 patients with prenatal myelomeningocele repair (including 14 who ultimately required CSF diversion surgery). Potential independent variables, including the Management of Myelomeningocele Study Index (a dichotomized variable based on the shunt-placement criteria from the Management of Myelomeningocele Study), postnatal DTI measures (fractional anisotropy and mean diffusivity in the genu of the corpus callosum and the posterior limb of internal capsule), fronto-occipital horn ratio at the time of DTI, gestational ages, and sex, were evaluated using stepwise logistic regression analysis to identify the most important predictors.RESULTS: The CSF diversion surgery index model showed that the Management of Myelomeningocele Study Index and fractional anisotropy in the genu of the corpus callosum were significant predictors (P < .05) of CSF diversion surgery. The predictive value of the CSF diversion surgery index was also affected by fractional anisotropy in the posterior limb of the internal capsule and sex with marginal effect (.05<P < .10), but not by the fronto-occipital horn ratio (P > .10). The overall CSF diversion surgery index model fit the data well with statistical significance (eg, likelihood ratio: P < .001), with the performance (sensitivity = 78.6%; specificity = 86.5%, overall accuracy = 84.8%) superior to all individual indices in sensitivity and overall accuracy, and most of the individual indices in specificity.CONCLUSIONS: The CSF diversion surgery index model outperformed all single predictor models and, with additional validation, may potentially be developed and incorporated into a sensitive and robust clinical tool to assist clinicians in hydrocephalus management.CDSICSF diversion surgery indexFAfractional anisotropyFOHRfronto-occipital horn ratiogCCgenu of the corpus callosumMDmean diffusivityMMCmyelomeningoceleMOMSManagement of Myelomeningocele StudyPLICposterior limb of the internal capsule ER -