PT  - JOURNAL ARTICLE
AU  - M. Koob
AU  - V. Laugel
AU  - M. Durand
AU  - H. Fothergill
AU  - C. Dalloz
AU  - F. Sauvanaud
AU  - H. Dollfus
AU  - I.J. Namer
AU  - J.-L. Dietemann
TI  - Neuroimaging In Cockayne Syndrome
AID  - 10.3174/ajnr.A2135
DP  - 2010 Oct 01
TA  - American Journal of Neuroradiology
PG  - 1623--1630
VI  - 31
IP  - 9
4099  - http://www.ajnr.org/content/31/9/1623.short
4100  - http://www.ajnr.org/content/31/9/1623.full
SO  - Am. J. Neuroradiol.2010 Oct 01; 31
AB  - CS is an autosomal recessive multisystem disorder, which is mainly characterized by neurologic and sensory impairment, cachectic dwarfism, and photosensitivity. We describe the neuroimaging features (MR imaging, 1H-MR spectroscopy, and CT) in the various clinical subtypes of CS from a cohort of genetically and biochemically proved cases. Hypomyelination, calcifications, and brain atrophy were the main imaging features. Calcifications were typically found in the putamen and less often in the cortex and dentate nuclei. Severe progressive atrophy was seen in the supratentorial white matter, the cerebellum, the corpus callosum, and the brain stem. Patients with early-onset disease displayed more severe hypomyelination and prominent calcifications in the sulcal depth of the cerebral cortex, but atrophy was less severe in late-onset patients. On proton MR spectroscopy, lactate was detected and Cho and NAA values were decreased. These combined neuroradiologic findings can help in the differential diagnosis of CS, distinguishing it from other leukoencephalopathies and/or cerebral calcifications in childhood.' ChocholineCrcreatineCSCockayne syndromeCOFScerebro-oculo-facio-skeletal syndromeFLAIRfluid-attenuated inversion recoveryNAAN-acetylaspartate