TY - JOUR T1 - Endarterectomy, Stenting, or Medical Treatment for Symptomatic Carotid Near-Occlusion: Results from CAOS, a Multicenter Registry Study JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. DO - 10.3174/ajnr.A7617 AU - A. Garcia-Pastor AU - A. Gil-Núñez AU - J.M. Ramirez-Moreno AU - N. González-Nafría AU - J. Tejada AU - F. Moniche AU - J.C. Portilla-Cuenca AU - P. Martínez-Sánchez AU - B. Fuentes AU - M.A. Gamero-García AU - M.A. de Leciñana AU - J. Masjuan AU - D.C. Verge AU - Y. Aladro AU - V. Parkhutik AU - A. Lago AU - A.M. de Arce-Borda AU - M. Usero-Ruiz AU - R. Delgado-Mederos AU - A. Pampliega AU - Á. Ximenez-Carrillo AU - M. Bártulos-Iglesias AU - E. Castro-Reyes AU - on behalf of the Stroke Project of the Spanish Cerebrovascular Diseases Study Group Y1 - 2022/08/18 UR - http://www.ajnr.org/content/early/2022/08/18/ajnr.A7617.abstract N2 - BACKGROUND AND PURPOSE: The treatment of symptomatic carotid near-occlusion is controversial. Our aim was to analyze the results of carotid endarterectomy and carotid artery stent placement in patients with symptomatic carotid near-occlusion and to identify factors related to technical failure, periprocedural complications, and restenosis.MATERIALS AND METHODS: We conducted a multicenter, prospective nonrandomized study. Patients with angiography-confirmed carotid near-occlusion were included. We assessed the revascularization rate and periprocedural stroke or death. Twenty-four-month clinical and carotid imaging follow-up was performed, and rates of carotid restenosis or occlusion, ipsilateral stroke, and mortality were analyzed. Carotid artery stent placement, carotid endarterectomy, and medical treatment were compared.RESULTS: One hundred forty-one patients were included. Forty-four carotid artery stent placement and 23 carotid endarterectomy procedures were performed within 6 months after the event. Complete revascularization was achieved in 83.6%, 81.8% in the carotid artery stent placement group and 87% with carotid endarterectomy (P = .360). Periprocedural stroke or death occurred in 6% (carotid artery stent placement = 2.3%; carotid endarterectomy = 13%; P = .077) and was not related to revascularization failure. The carotid restenosis or occlusion rate was 8.3% (5% restenosis, 3.3% occlusion); with carotid artery stent placement it was 10.5%; and with carotid endarterectomy it was 4.5% (P = .419). The 24-month cumulative rate of ipsilateral stroke was 4.8% in the carotid artery stent placement group, 17.4% for carotid endarterectomy, and 13.1% for medical treatment (P = .223). Mortality was 12%, 4.5%, and 5.6%, respectively (P = .422). Revascularization failure and restenosis occurred more frequently in patients with full collapse compared with patients without full collapse (33.3% versus 5.6%, P = .009; 21.4% versus 2.9%, P = .032, respectively).CONCLUSIONS: Carotid artery stent placement and carotid endarterectomy are associated with high rates of failure and periprocedural stroke. Carotid near-occlusion with full collapse appears to be associated with an increased risk of technical failure and restenosis. Carotid near-occlusion revascularization does not seem to reduce the risk of stroke at follow-up compared with medical treatment.CAScarotid artery stent placementCEAcarotid endarterectomyCHScerebral hyperperfusion syndromeCNOcarotid near-occlusionIQRinterquartile range ER -