PT - JOURNAL ARTICLE AU - E.L. Wignall AU - P.D. Griffiths AU - N.G. Papadakis AU - I.D. Wilkinson AU - L.I. Wallis AU - O. Bandmann AU - P.E.E. Cowell AU - N. Hoggard TI - Corpus Callosum Morphology and Microstructure Assessed Using Structural MR Imaging and Diffusion Tensor Imaging: Initial Findings in Adults with Neurofibromatosis Type 1 AID - 10.3174/ajnr.A2005 DP - 2010 May 01 TA - American Journal of Neuroradiology PG - 856--861 VI - 31 IP - 5 4099 - http://www.ajnr.org/content/31/5/856.short 4100 - http://www.ajnr.org/content/31/5/856.full SO - Am. J. Neuroradiol.2010 May 01; 31 AB - BACKGROUND AND PURPOSE: Imaging studies have shown that children with NF-1 have increased brain volumes compared with age-matched controls and the CCs are disproportionately large. The purpose of this study was to determine if the CC in adults with NF-1 differed from that in matched controls by using DTI and volumetric imaging. MATERIALS AND METHODS: MR imaging with DTI was performed in 10 adults with NF-1 and in 10 age-, sex-, and handedness-matched controls by using a 3T system. Total brain volumes and the areas and central lengths of the CC were calculated, along with the radial width of callosal subdivisions, in the 2 groups. RESULTS: Our results showed that the total brain volume was not significantly different between adults with NF-1 and matched controls. The length and total cross-sectional area of the CC were statistically larger in adults with NF-1 compared with controls (approximately 10% longer and 20% greater area). On DTI we found a preservation of the primary eigenvalue with increases in the minor eigenvalues at the genu. CONCLUSIONS: We have shown that the increased size of the CC found in children with NF-1 is also present in adults with the syndrome, whereas no difference in total brain volume was found. CCcorpus callosumCIconfidence intervalDTIdiffusion tensor imagingFAfractional anisotropyFLAIRfluid-attenuated inversion recoveryICCintraclass correlation coefficientsNF-1neurofibromatosis type 1