PT  - JOURNAL ARTICLE
AU  - L. Saba
AU  - R. Sanfilippo
AU  - R. Montisci
AU  - G. Mallarini
TI  - Assessment of Intracranial Arterial Stenosis with Multidetector Row CT Angiography: A Postprocessing Techniques Comparison
AID  - 10.3174/ajnr.A1976
DP  - 2010 May 01
TA  - American Journal of Neuroradiology
PG  - 874--879
VI  - 31
IP  - 5
4099  - http://www.ajnr.org/content/31/5/874.short
4100  - http://www.ajnr.org/content/31/5/874.full
SO  - Am. J. Neuroradiol.2010 May 01; 31
AB  - BACKGROUND AND PURPOSE: It was demonstrated the some patients with stroke have intracranial stenosis of 50% or greater and the identification of intracranial arterial stenosis is extremely important in order to plan a correct therapeutical approach. The aim of this study was to assess the image quality and intertechnique agreement of various postprocessing methods in the detection of intracranial arterial stenosis. MATERIAL AND METHODS: Eighty-five patients who were studied by using a multidetector row CT scanner were retrospectively analyzed. A total of 2040 segments were examined in the 85 subjects. Intracranial vasculature was assessed by using MPR, CPR, MIP, and VR techniques. Two radiologists reviewed the CT images independently. Cohen weighted κ statistic was applied to calculate interobserver agreement and for image accuracy for each reconstruction method. Sensitivity, specificity, PPV, and NPV were also calculated by using the consensus read as the reference. RESULTS: Two hundred fifteen (10.5%) stenosed artery segments were identified by the observers in consensus. The best intermethod κ values between observers 1 and 2 were obtained by VR and MIP (κ values of 0.878 and 0.861, respectively), whereas MPR provided the lowest value (κ value of 0.282). VR showed a sensitivity for detecting stenosed segments of 88.8% and 91.6% for observers 1 and 2, respectively. The highest positive predictive value was also obtained by VR at 95% and 99% for observers 1 and 2, respectively. Image accuracy obtained by using VR was the highest among all reconstruction methods in both observers (185/255 and 177/255 for observers 1 and 2, respectively). CONCLUSIONS: The results of our study suggest that VR and MIP techniques provide the best interobserver and intertechnique concordance in the analysis of intravascular cranial stenosis. CPRcurved planar reconstructionCTACT angiographyDSAdigital subtraction angiographyHUHounsfield unitICAinternal carotid arteryMDCTAmultidetector row CT angiographyMIPmaximum intensity projectionMPRmultiplanar reconstructionMRAMR angiographyNASCETNorth American Symptomatic Carotid Endarterectomy TrialNCnot calculatedNPVnegative predictive valuePPVpositive predictive valueVRvolume rendering