RT Journal Article
SR Electronic
T1 Five-Year Follow-Up in Elastase-Induced Aneurysms in Rabbits
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1236
OP 1239
DO 10.3174/ajnr.A2056
VO 31
IS 7
A1 Y. Ding
A1 D. Dai
A1 R. Kadirvel
A1 D.A. Lewis
A1 D.F. Kallmes
YR 2010
UL http://www.ajnr.org/content/31/7/1236.abstract
AB BACKGROUND AND PURPOSE: There is no report regarding patency of elastase-induced aneurysms for more than a 2-year period. Our aim was to report aneurysm patency rates up to 5 years in the elastase-induced aneurysm model in rabbits. MATERIALS AND METHODS: Twenty-five elastase-induced aneurysms were created in New Zealand white rabbits and followed for up to 5 years. Thirteen (52%) rabbits died during follow-up for reasons unrelated to the aneurysms. DSA was performed at 1 month and at 2 and 5 years in the 12 surviving subjects. Aneurysm patency and dimensions, including neck diameter and aneurysm width and height, were evaluated at each time point in relation to external sizing devices. Differences of aneurysm sizes (neck width and aneurysm width and height) among time points were compared by using the Student t test. RESULTS: Eleven (92%) of the 12 aneurysms in the subjects that survived for 5 years remained fully patent throughout follow-up. A single narrow-neck aneurysm showed partial thrombosis at the 2- and 5-year time points. CONCLUSIONS: Experimental elastase-induced aneurysms in rabbits demonstrate high rates of patency up to 5 years following creation. When planning for very long-term studies, investigators should plan for relatively high rates of mortality unrelated to aneurysm pathology. APanteroposteriorDSAdigital subtraction angiographyIADSAintra-arterial DSAIVDSAintravenous DSARCCAright common carotid artery