Baseline Characteristics | Control Group (n = 29) | AD Group (n = 42) | P value* |
---|---|---|---|
Sociodemographics and anthropometrics | |||
Mean age at observation ± SD (y) | 69 ± 9 | 76 ± 8 | .0007 |
(range) | (51–82) | (57–90) | |
Women | 19 (65%) | 33 (75%) | NS |
Mean education ± SD (y) | 9.4 ± 4.9 | 6.0 ± 3.3 | .001 |
(range) | (2–18) | (2–17) | |
Mean head size on axial plane ± SD, cm2 | 136 ± 12 | 138 ± 12 | NS |
(range) | (115–164) | (117–166) | |
Dementia-related variables | |||
MMSE score† | 27.0 ± 0.9 | 21.1 ± 2.3 | <.0001 |
(range) | (23.4–27.4) | (18–27) | |
CDR of 0/.5/1/2 or 3 | 29/0/0/0 | 0/18/24/0 | <.0001 |
Mean disease duration ± SD (mo) | — | 37 ± 20 | |
(range) | — | (9–96) | |
ApoE ε4 allele‡ | 8/56 (14%) | 32/82 (39%) | .003 |
Lacunes | 9 (33%) | 7 (17%) | NS |
Mean leukoaraiosis score ± SD | 5.7 ± 5.0 | 6.9 ± 5.2 | NS |
(range) | (0–17) | (0–16) | |
Physical diseases | |||
Ischemic heart disease | 3 (9%) | 6 (14%) | NS |
Cancer | 3 (9%) | 6 (14%) | NS |
Hypertension | 10 (35%) | 18 (41%) | NS |
Diabetes mellitus | 1 (4%) | 2 (5%) | NS |
* t test for independent samples, or chi-square test.
† In control subjects, computed on the basis of the telephone version of the test (26, 27).
‡ Data available for 28 historical control subjects and 41 patients with AD (12, 16).