TABLE 1:

Baseline characteristics of the CT study group

Baseline CharacteristicsControl Group (n = 29)AD Group (n = 42)P value*
Sociodemographics and anthropometrics
 Mean age at observation ± SD (y)69 ± 976 ± 8.0007
  (range)(51–82)(57–90)
 Women19 (65%)33 (75%)NS
 Mean education ± SD (y)9.4 ± 4.96.0 ± 3.3.001
  (range)(2–18)(2–17)
 Mean head size on axial plane ± SD, cm2136 ± 12138 ± 12NS
  (range)(115–164)(117–166)
Dementia-related variables
 MMSE score27.0 ± 0.921.1 ± 2.3<.0001
  (range)(23.4–27.4)(18–27)
 CDR of 0/.5/1/2 or 329/0/0/00/18/24/0<.0001
 Mean disease duration ± SD (mo)37 ± 20
  (range)(9–96)
 ApoE ε4 allele8/56 (14%)32/82 (39%).003
 Lacunes9 (33%)7 (17%)NS
 Mean leukoaraiosis score ± SD5.7 ± 5.06.9 ± 5.2NS
  (range)(0–17)(0–16)
Physical diseases
 Ischemic heart disease3 (9%)6 (14%)NS
 Cancer3 (9%)6 (14%)NS
 Hypertension10 (35%)18 (41%)NS
 Diabetes mellitus1 (4%)2 (5%)NS
  • * t test for independent samples, or chi-square test.

  • In control subjects, computed on the basis of the telephone version of the test (26, 27).

  • Data available for 28 historical control subjects and 41 patients with AD (12, 16).