Demographic, clinical, and MR imaging characteristics of healthy volunteers and patients*
| HV (n = 24) | RR (n = 13) | SP (n = 11) | |
|---|---|---|---|
| Age (yr) | 41.9 ± 8.3 | 41.7 ± 6.1 | 46.9 ± 9.6 |
| EDSS | – | 2.2 ± 1.2† | 5.9 ± 1.0† |
| EDSS-motor | – | 1.7 ± 1.1† | 3.5 ± 0.8† |
| EDSS-sens | – | 1.2 ± 1.0‡ | 2.2 ± 0.9‡ |
| DD | – | 11.1 ± 6.5‡ | 17.6 ± 4.7‡ |
| PASAT | – | 47.5 ± 15.9 | 37.1 ± 11.1 |
| T1LV | – | 3.82 ± 3.43 | 6.08 ± 3.70 |
| T2LV | – | 14.41 ± 10.79 | 17.89 ± 14.95 |
| BPF | 0.84 ± 0.02§ | 0.80 ± 0.04‡§ | 0.75 ± 0.04‡§ |
| CELs | – | 1 | 0 |
| Thalamic FA | 0.276 ± 0.017 | 0.307 ± 0.022§ | 0.308 ± 0.017§ |
| Thalamic MD | 0.737 ± 0.019 | 0.751 ± 0.046 | 0.764 ± 0.028‖ |
Note:— –indicates not applicable; HV, healthy volunteers; DD, disease duration; CELs, number of patients with contrast-enhancing lesions; EDSS-sens, partial sensory score of the EDSS; EDSS, Expanded Disability Status Scale; PASAT, Paced Auditory Serial Addition Task; BPF, brain parenchymal fraction; LV, lesion volume; FA, fractional anisotropy; MD, mean diffusivity; RR, relapsing-remitting; SPMS, secondary-progressive multiple sclerosis.
* Data are mean ± SD. T1LV and T2LV are given in cubic centimeters, BPF and FA values are dimensionless, and MD values are given in mm2/s × 10−3.
† P < .001, comparison between RR and SPMS.
‡ P < .05, comparison between RR and SPMS.
§ P < .001, compared with HVs.
‖ P < .05, compared with HVs.