Healthy Subjects | Patients | |||
---|---|---|---|---|
RRMS | SPMS | PPMS | ||
M/F | 4/6 | 8/12 | 6/13 | 12/19 |
Mean age (years) | 42.6 (31–58) | 35.9 (25–43) | 49.3 (35–58) | 50.1 (25–68) |
Median EDSS score | NA | 3.0 (0.0–5.0) | 6.0 (4.0–8.0) | 6.0 (2.5–7.0) |
Median disease duration (years) | NA | 5 (0–20) | 16 (6–34) | 10 (2–26) |
Baseline lesion volume (mL) | ||||
On T2-weighted images | NA | 13.9 (10.6) | 21.7 (17.3) | 21.0 (16.9) |
On T1-weighted images | NA | 3.1 (3.6) | 8.5 (7.3) | 8.2 (6.9) |
Lesion volume change (%) | ||||
On T2-weighted images | NA | 9.4 | 3.8 | 4.9 |
On T1-weighted images | NA | 3.4 | 11.0 | 4.3 |
Baseline NBV (mL) | 1602 (80) | 1517 (70) | 1464 (90) | 1473 (70) |
Note.—Data in parentheses are the range or standard deviation. NA indicates not applicable.