Comparison of automated and manual AIF parameters

Subject	ΔA₀ (sec⁻¹)	ΔA₁ (sec)	ΔA₂ (sec)	d (mm)	Correlation r^*
Subject	ΔA₀ (sec⁻¹)	ΔA₁ (sec)	ΔA₂ (sec)	d (mm)	Tmax	CBF
1	21.52	0.69	0.34	11.3	0.91	0.94
2	17.09	1.32	−0.17	15.9	0.87	0.92
3	0	0	0	0.9	1.00	1.00
4	19.75	−0.59	−0.37	7.1	0.82	0.66
5	47.48	−2.98	−1.23	11.4	0.70	0.60
6	11.39	0.32	−0.88	32.2	0.82	0.72
7	29.06	−0.39	−1.28	18.9	0.68	0.74
8	37.22	0.57	−0.68	18.2	0.76	0.83
9	12.83	0.12	0.76	6.0	0.75	0.72
10	32.61	1.30	−0.39	18.2	0.81	0.87
11	25.22	−0.79	−0.17	30.6	0.87	0.86
12	−4.32	−2.65	−2.15	35.9	0.81	0.82
13	1.24	−0.24	−0.30	37.8	0.73	0.82
14	27.30	−2.46	−0.24	24.0	0.74	0.60
15	15.26	−0.19	−0.07	3.0	0.85	0.88
16	17.83	0.36	1.36	2.7	0.80	0.77
17	2.71	−5.25	−2.18	35.0	0.54	0.68
18	0	0	0	1.3	1.00	1.00
19	19.27	−0.62	−0.09	16.9	0.87	0.87
20	11.78	0.71	−0.87	44.5	0.82	0.89
21	10.17	−0.19	−0.30	11.6	0.85	0.87
22	0	0	0	1.3	1.00	1.00
Mean	16.16	−0.50	−0.41	17.5	0.82	0.82
SD	13.49	NA	NA	13.45	0.11	0.12
P value	<0.001	0.374	0.018	NA	NA	NA

Note.—Differences were computed as the automated AIF parameter − manual AIF parameter. A₀ = curve height (maximum concentration of contrast agent), A₁ = curve center (time to peak), A₂ = curve width, d = distance between automated and manual AIF pixels, NA = not applicable.
* Between automated and manual maps.