Characteristics of neurotoxic events and MRI findings

PatientTime between Diagnosis and Event (months)EventTime between IT MTX and Event (days)Time between Event and Initial MRI (days)1st MRI DWI FindingsTime between Initial and Follow-up MRI (days)Follow-up MRI FLAIR FindingsDuration of Symptoms
12R hemiparesis, headache, dysmetria80Restricted L > R5Increased1 mo
28Aphasia, headache, R hemiparesis71Restricted L > RNDND4 d
35L hemiparesis111Restricted R > L59Increased7 d
411R hemiparesis61Restricted L only4Increased7 d
511R hemiparesis72Restricted L > R20Increased7 d
63Aphasia111Restricted R = L23Increased1 d
  • Note.—R indicates right; L, left; IT MTX, intrathecal methotrexate; DWI, diffusion-weighted imaging; ND, not done; FLAIR, fluid attenuated inversion recovery sequence.