TABLE 2:

Combination of two MR imaging signs of tumor recurrence versus radiation necrosis results

CC MIDCC SUBCC MEFCC SPWCC SEPMID SUBMID MEFMID SPWMID SEPSUB MEFSUB SPWSUB SEPMEF SPWMEF SEPSPW SEPPathologic Diagnosis
Presence51071087475912109710Necrosis
Absence191417141617201719151214151714Necrosis
Presence122119131213115420141312115Tumor
Absence18911171817192526101617181925Tumor
P value*.15.05.021.78.4.13.33.48.05111.77.07
Sign favors diagnosis of:TumorTumorTumorNeitherTumorTumorTumorNeitherNeitherTumorNeitherNeitherTumorTumorNecrosis
    Se (%)40.07063.3N/A404336.7N/AN/A66.7N/AN/A4036.741.7
    Sp (%)79.258.370.8N/A66.770.883.3N/AN/A62.5N/AN/A62.570.883.3
    PPV (%)70.667.773.1N/A606573.3N/AN/A69N/AN/A57.161.166.7
    NPV (%)51.460.960.7N/A47.15051.3N/AN/A60N/AN/A45.547.264.1
Accuracy57.464.866.7N/A51.955.657.4N/AN/A64.8N/AN/A5051.964.8
  • CC indicates corpus callosum involvement; MID, midline spread; SUB, subependymal spread; MEF, new discrete multiple enhancing foci; SPW, “spreading wavefront” appearance; SEP, septum pellucidum involvement; Se, sensitivity; Sp, specificity; PPV, positive predictive values; and NPV, negative predictive values.

  • * Fisher’s exact 2-tailed test.