Combination of two MR imaging signs of tumor recurrence versus radiation necrosis results
| CC MID SUB | CC MID MEF | CC MID SPW | CC MID SEP | CC SUB MEF | CC SUB SPW | CC SUB SEP | CC MEF SPW | CC MEF SEP | CC SPW SEP | Pathologic Diagnosis | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Presence | 11 | 8 | 11 | 9 | 13 | 16 | 14 | 13 | 11 | 14 | Necrosis |
| Absence | 25 | 28 | 25 | 27 | 23 | 20 | 22 | 23 | 25 | 22 | Necrosis |
| Presence | 23 | 21 | 15 | 14 | 30 | 24 | 23 | 22 | 21 | 15 | Tumor |
| Absence | 22 | 24 | 30 | 31 | 15 | 21 | 22 | 23 | 24 | 30 | Tumor |
| P value* | .07 | .04 | .81 | .62 | .01 | .50 | .37 | .27 | .17 | .64 | |
| Sign favors diagnosis of | Tumor | Tumor | Tumor | Tumor | Tumor | Tumor | Tumor | Tumor | Tumor | Neither | |
| Se (%) | 51.1 | 46.7 | 33.3 | 31.1 | 66.7 | 53.3 | 51.1 | 48.9 | 46.7 | N/A | |
| Sp (%) | 69.4 | 77.8 | 69.4 | 75.0 | 63.9 | 55.6 | 61.1 | 63.9 | 69.4 | N/A | |
| PPV (%) | 67.6 | 72.4 | 57.7 | 60.9 | 69.8 | 60.0 | 62.2 | 62.9 | 65.6 | N/A | |
| NPV (%) | 53.2 | 53.8 | 45.5 | 46.6 | 60.5 | 48.8 | 50.0 | 50.0 | 51.0 | N/A | |
| Accuracy (%) | 59.3 | 60.5 | 49.4 | 50.6 | 65.4 | 54.3 | 55.6 | 55.6 | 56.8 | N/A |
CC indicates corpus callosum involvement; MID, midline spread; SUB, subependymal spread; MEF, new discrete multiple enhancing foci; SPW, “spreading wavefront” appearance; SEP, septum pellucidum involvement; Se, sensitivity; Sp, specficity; PPV, positive predictive values; and NPV, negative predictive values.
* Fisher’s exact 2-tailed test.