Total number of patients evaluable at each time and proportion with leukoencephalopathy*

Low RiskStandard/High Risk
LE/Eval (n)T1T2LE/Eval (n)T1T2
Post 1 IV-MTX3/213147/2342
Post 4 IV-MTX12/2011612/21123
Post 7 IV-MTX14/2113918/211413
End of Therapy8/20768/1765
  • Note.—LE indicates leukoencephalopathy; Eval, evaluated; IV-MTX, intravenous methotrexate.

  • * Note that quantitative T1 and T2 measurements were acquired at the end of the imaging studies and often suffered from motion of patients, making them inevaluable.