Estimated mean ± SD NAA concentrations at each institution.

InstitutionSubjectsScanner Field, Manufacturer, ModelMean WBNAA (mmol/L)SD (Unadjusted) (mmol/L)SD (adjusted)
Firstn = 231.5 T, Siemens, Vision11.71.31.3
Secondn = 311.5 T, Siemens, SP6312.31.11.1
Thirdn = 241.5 T, Siemens, Vision12.61.21.2
n = 123.0 T, Siemens, Trio11.71.11.1
Fourthn = 114.0 T, GE, Signa 5.x12.81.51.5
Totaln = 10112.2*1.2*1.2
  • Note:—WBNAA indicates whole-brain N-acetylaspartate. The SDs are presented as both unadjusted and adjusted with respect to confounding effects from age and gender (differences were in second decimal digit or smaller).

  • * Average of all subjects at all institutions.