Baseline characteristics of patients with acute ischemic stroke treated with IA thrombolysis
| Variable | Age <80 years (n = 81) | Age ≥80 years (n = 33) |
|---|---|---|
| Mean age (range), years | 64 (25–79) | 86 (80–97) |
| Female, n (%) | 38 (47%) | 20 (61%) |
| Current tobacco use, n (%) | 19 (23%) | 7 (21%) |
| Hypertension, n (%) | 58 (72%) | 19 (58%) |
| Diabetes mellitus, n (%) | 13 (16%) | 4 (12%) |
| Hyperlipidemia, n (%) | 27 (33%) | 9 (27%) |
| Coronary artery disease, n (%) | 25 (31%) | 10 (30%) |
| Medium risk cardioembolic source, n (%) | 11 (14%) | 4 (12%) |
| High-risk cardioembolic source, n (%) | 39 (48%) | 20 (61%) |
| Prior stroke/TIA, n (%) | 17 (21%)* | 14 (42%)* |
| Peripheral vascular disease, n (%) | 2 (2%) | 3 (1%) |
| Antiplatelet therapy, n (%) | 31 (38%) | 10 (30%) |
| Warfarin therapy, n (%) | 11 (14%) | 7 (21%) |
| Weight, kg, mean ± SD | 75.8 ± 13.0* | 66.8 ± 10.8* |
| BP peak pretreatment, mm Hg, mean ± SD | ||
| Systolic | 160 ± 30 | 168 ± 38 |
| Diastolic | 86 ± 18 | 92 ± 22 |
| Glucose, mg/dL, mean ± SD | 149 ± 46 | 146 ± 96 |
| Platelets, ×103/μL, mean ± SD | 233 ± 83 | 225 ± 68 |
| Pretreatment NIHSS score, median (range) | 16 (2–38) | 17 (2–25) |
| Presence of hyperdense MCA sign, n (%) | 15 (19%) | 5 (15%) |
| Pathogenic mechanism | ||
| Cardioembolic, n (%) | 25 (31%) | 12 (36%) |
| Noncardioembolic, n (%) | 37 (46%) | 16 (48%) |
| Undetermined, n (%) | 19 (23%) | 5 (16%) |
| Location: anterior circulation, n (%) | 67 (83%) | 29 (88%) |
| Target vessel localization, n (%) | ||
| Extracranial internal carotid artery | 12 (15%) | 2 (6%) |
| Intracranial internal carotid artery | 10 (12%) | 5 (15%) |
| Both intracranial and extracranial internal carotid artery | 1 (1%) | 0 (0%) |
| Middle cerebral artery | 44 (54%) | 17 (52%) |
| Anterior cerebral artery | 4 (5%) | 2 (6%) |
| Posterior cerebral artery | 5 (5%) | 1 (3%) |
| Vertebrobasilar | 11 (14%) | 4 (12%) |
Note:—IA indicates intra-arterial; TIA, transient ischemic attack; BP, blood pressure; NIHSS, National Institutes of Health Stroke Scale; MCA, middle cerebral artery.
* P ≤ 0.05