Comparison between the ssT1 and fpT2* methods: theoretical and practical considerations
| ssT1 Method | fpT2* Method | |
|---|---|---|
| Theoretical considerations | ||
| Shape of contrast agent concentration time curve | Bi-exponential decay | Gamma-variate |
| Concentration of intravascular contrast agent | Lower | Higher |
| Ktrans for normal brain tissue | Zero | Negligible or very small, but not zero |
| Rate of contrast agent movement from intravascular to extravascular space within a single voxel of tissue | Slower | Faster |
| Practical considerations | ||
| Spatial resolution | Higher | Lower |
| Subjectivity to susceptibility artifact | No | Yes |
| Imaging time | Longer (>6 min) | Shorter (<1.5 min) |
| Postprocessing algorithm complexity | Higher | Lower |