Table 1:

Response criteria for primary central nervous system lymphoma

ResponseBrain ImagingCorticosteroid DoseEye Examination FindingsCSF Cytology Findings
CRNo contrast enhancementNoneNormalNegative
CRuNo contrast enhancementAnyNormalNegative
Minimal abnormalityAnyMinor RPE abnormalityNegative
PR50% Decrease in enhancing tumorIrrelevantMinor RPE abnormality or normalNegative
No contrast enhancementIrrelevantDecrease in vitreous cells or retinal infiltratePersistent or suspicious
PD25% Increase in lesionIrrelevantRecurrent or new ocular diseaseRecurrent or positive
Any new site of disease: CNS or systemic
  • Note:—CRu indicates unconfirmed complete response; RPE, retinal pigment epithelium.