Table 3:

The differentially expressed genes are grouped into their respective molecular pathways

Proteolytic enzymesApoptosis of smooth muscle cells
    Cathepsin L+Fas antigen spliced variant
    Cellular disintegrin ADAM 6eFast skeletal muscle troponin C mRNA
    Hyperoxia induced (HI) 1 gene encoding a TIMP+Galectin-3+
    Matrix metalloproteinase-2+Heat shock protein 47+
    Matrix metalloproteinase-9+Muscle α -actinin subunit, N′-terminal region
    Matrix metalloproteinase-12+Myosin heavy chain (MHC)
    Metallo-elastase, macrophage+Myosin light chain 2
    Osteonectin = SPARC+PPAR γ 3+
    Tissue inhibitor of metalloproteinase-2 (TIMP-2)+p53 protein
    Tissue inhibitor of metalloproteinase-4 (TIMP-4)+Secreted frizzled-related protein 2+
Coagulation cascadeInflammatory cell recruitment
    Coagulation factor VIIAdhesion molecule VCAM-1 (VCAM-1)+
    Factor XIEndothelial differentiation gene 1 protein+
    Glycoprotein IIb (GPIIb)+Interferon γ
    Glycoprotein IIIa (GPIIIa)+Interleukin-1 receptor antagonist+
    Haptoglobin mRNA+Interleukin-2
    Heme oxygenase-1 (HO1)+Interleukin-8 receptor
    Heme oxygenase-2MHC class II RLA-DR-α gene+
    Platelet-derived growth factor-β+Monocyte chemoattractant protein-1 (MCP-1)+
    Thrombomodulin precursor (inhibitor of coagulation)Neutrophil-activating peptide 78 (ENA-78)
    Thrombospondin 2-like protein (THBS2)+Neutrophil attractant/activation protein-1 (NAP-1)
    Tissue-type plasminogen activator mRNA+
ECM proteinsOxidative stress
    α-1 type V collagen (COL5A1)A1 Adenosine receptor+
    α-1 type X collagen+A3 Adenosine receptor
    α-2 type I collagenAlcohol dehydrogenase, class I+
    α-3 type IV collagen+*Apolipoprotein B
    Bone morphogenetic protein 2 (BMP-2)Apolipoprotein E+
    Bone morphogenetic protein 7 (BMP-7)Atrial natriuretic polypeptide+
    Decorin=proteoglycanClass II alcohol dehydrogenase, isozyme 1+
    Fibroblast growth factorClone pApoD-L) apolipoprotein D (apoD)+
    Insulin-like growth factor 1 precursor (IGF-1)+CYP4B1 isoform
    Osteopontin+Endothelin B receptor
    Transforming growth factor-β 2Endothelin converting enzyme (ECE1)
    Type VIII collagen α -1 chainEndothelin receptor type A
Glutathione S-transferase
Inducible nitric oxide synthase (NOS2)
NADPH-cytochrome P450 reductase
Neuronal nitric oxide synthase NOS1+
Protein inhibitor of neuronal nitric oxide synthase+
Vascular endothelial growth factor receptor 3+
  • Note:—+ indicates that the gene was overexpressed in the aneurysm; −, the gene was underexpressed in the aneurysm.