Characteristics of subject groups
| PP MS | RR MS | SP MS | Controls | |
|---|---|---|---|---|
| No. of subjects (M/F) | 13 (7/6) | 36 (11/25) | 18 (7/11) | 23 (12/11) |
| Age (y) | 57.2 ± 6.3 | 39.0 ± 7.3 | 44.3 ± 10.5 | 30.6 ± 7.4 |
| Supratentorial lesion load (range) (mL) | 8.6 ± 8.7 (0.2–27.8) | 8.8 ± 9.4 (0.3–41.2) | 14.6 ± 13.1 (2.5–54.7) | |
| Infratentorial lesion load (range) (mL) | 0.2 ± 0.3 (0.0–0.8) | 0.2 ± 0.3 (0.0–0.9) | 0.5 ± 1.0 (0.0–4.2) | |
| Normalized brain volume (mL) | 1417 ± 48 | 1473 ± 64 | 1406 ± 52 | 1518 ± 42 |
| Median EDSS score (range) | 4.5 (3.0–6.5) | 2.0 (1.0–4.5) | 6.0 (2.5–8.0) | |
| MSFC score | 0.32 ± 0.19 | 0.56 ± 0.31 | −0.27 ± 0.72 |
Note:— PP MS, RR MS, and SP MS indicate, respectively, primary progressive, relapsing-remitting, and secondary progressive multiple sclerosis; EDSS, expanded disability status scale; MSFC, multiple sclerosis functional composite.