Univariate analysis of MRS findings
| Metabolite Ratio | Childrenwith CI(n = 12) | Childrenwithout CI(n = 7) | Control Group(n = 10) | P |
|---|---|---|---|---|
| WM | ||||
| NAA/Cr | 1.94 ± 0.49 | 2.17 ± 0.26 | 2.11 ± 0.36 | .450 |
| Cho/Cr | 0.94 ± 0.21 | 0.97 ± 0.12 | 0.83 ± 0.19 | .301 |
| mIns/Cr | 0.57 ± 0.18 | 0.43 ± 0.12 | 0.40 ± 0.10 | .032 |
| GM | ||||
| NAA/Cr | 2.05 ± 0.41 | 2.01 ± 0.50 | 2.12 ± 0.21 | .842 |
| Cho/Cr | 0.45 ± 0.08 | 0.45 ± 0.07 | 0.48 ± 0.07 | .668 |
| mIns/Cr | 0.47 ± 0.88 | 0.36 ± 0.11 | 0.45 ± 0.66 | .046 |
Note:—CI indicates cognitive impairment; WM, white matter; NAA, N-acetylaspartate; Cr, creatine; Cho, choline; mIns, myo-inositol; GM, gray matter. Groups A and B indicate children with and without cognitive impairment, respectively.