Table 1:

MD and FA histogram-derived measures of brain tissue, gray matter, and white matter from patients with RNMO and control subjects

RNMOControlsP* (95% CI)
Brain tissue
    Average MD (×10−3 mm2 s−1)0.946 ± 0.0220.909 ± 0.031<.001
(0.934–0.958)(0.893–0.925)(0.018 to 0.056)
    Mean MD peak height (‰)10.326 ± 0.65711.224 ± 1.260.017
(9.975–10.676)(10.552–11.895)(−1.624 to −0.172)
    Mean MD peak location (×10−3 mm2 s−1)0.777 ± 0.0220.764 ± 0.025.136
(0.765–0.789)(0.751–0.778)(−0.004 to 0.030)
    Average FA0.250 ± 0.0080.253 ± 0.009.356
(0.246–0.254)(0.248–0.258)(−0.009 to 0.003)
    Mean FA peak height (‰)4.109 ± 0.2134.090 ± 0.272.828
(3.996–4.222)(3.945–4.235)(−0.157 to 0.195)
    Mean FA peak location0.127 ± 0.0090.125 ± 0.010.577
(0.123–0.132)(0.120–0.131)(−0.005 to 0.009)
White matter
    Average MD (×10−3 mm2 s−1)0.822 ± 0.0160.803 ± 0.019.004
(0.813–0.830)(0.793–0.812)(0.007 to 0.032)
    Mean MD peak height (‰)15.856 ± 0.88916.310 ± 1.402.283
(15.382–16.329)(15.563–17.057)(−1.301 to 0.393)
    Mean MD peak location (×10−3 mm2 s−1)0.760 ± 0.0220.744 ± 0.019.042
(0.748–0.771)(0.734–0.754)(0.001 to 0.030)
    Average FA0.333 ± 0.0120.345 ± 0.016.020
(0.327–0.339)(0.336–0.353)(−0.022 to −0.002)
    Mean FA peak height (‰)2.614 ± 0.1792.383 ± 0.180.001
(2.519–2.709)(2.288–2.480)(0.101 to 0.360)
    Mean FA peak location0.216 ± 0.0340.254 ± 0.063.043
(0.199–0.234)(0.221–0.288)(−0.074 to −0.001)
Gray matter
    Average MD (×10−3 mm2 s−1)1.057 ± 0.0370.992 ± 0.053<.001
(1.037–1.077)(0.964–1.020)(0.032 to 0.098)
    Mean MD peak height (‰)7.368 ± 0.8898.913 ± 1.707.003
(6.894–7.842)(8.003–9.822)(−2.527 to −0.562)
    Mean MD peak location (×10−3 mm2 s−1)0.833 ± 0.0160.809 ± 0.017<.001
(0.825–0.842)(0.800–0.818)(0.013 to 0.036)
  • Note:—RNMO indicates relapsing neuromyelitis optica; MD, mean diffusivity; FA, fractional anisotropy. Values are expressed as means ± SD (95% confidence interval).

  • * Statistical analysis: Student t test for independent samples; P < .005 is considered significant.