Table 1:

Lesions demonstrating Rosenthal fibers

CategoryExamples
ReactiveParenchyma surrounding slowly growing, low-grade tumorsHemangioblastoma, craniopharyngioma
Parenchyma surrounding cystsSyringomyelia, pineal cyst
Parenchyma surrounding vascular malformationsArteriovenous malformations, cavernomas
Parenchyma surrounding chronic inflammationMultiple sclerosis
NeoplasticPilocytic astrocytoma, ganglioglioma, pleomorphic xanthoastrocytoma
Genetic/metabolicAlexander disease
  • Note:—This table has been modified from refs. 12 and 18. With permission.