Alcoholics: rank correlations of 1H-MRS, MTR, and ADC and grading of hepatic encephalopathy
| Alcoholics, Mean (±SD) | Correlation (Spearman-Rho) | ||||||
|---|---|---|---|---|---|---|---|
| Controls, Mean (±SD) | HE 0 | mHE | HE1 | HE2 | r | P | |
| 1H-MRS, n = 34 | n = 10 | n = 6 | n = 7 | n = 5 | n = 6 | ||
| Basal ganglia | |||||||
| mlns/Cr** | 0.784 (0.570) | 0.256** (0.198) | 0.260** (0.214) | 0.347* (0.191) | 0.296* (0.247) | .03 | .889 |
| NAA/Cr | 1.670 (0.252) | 1.623 (0.321) | 1.453 (0.204) | 1.645 (0.185) | 1.559 (0.164) | .03 | .896 |
| Cho/Cr** | 0.267 (0.041) | 0.205** (0.032) | 0.186** (0.041) | 0.217 (0.053) | 0.203* (0.049) | .01 | .980 |
| Glx/Cr* | 1.513 (0.556) | 2.079* (0.417) | 2.795** (0.618) | 2.597** (0.724) | 2.516 (1.747) | .09 | .669 |
| Occipital lobe | |||||||
| mins/Cr** | 0.823 (0.099) | 0.295* (0.296) | 0.272** (0.191) | 0.310** (0.103) | 0.252** (0.158) | .12 | .567 |
| NAA/Cr | 1.708 (0.175) | 1.920 (0.283) | 1.877* (0.118) | 1.807 (0.262) | 1.914 (0.365) | −.11 | .601 |
| Cho/Cr | 0.258 (0.042) | 0.257 (0.056) | 0.225 (0.055) | 0.253 (0.044) | 0.226 (0.036) | −.12 | .572 |
| Glx/Cr** | 1.413 (0.489) | 2.071 (0.643) | 2.229** (0.919) | 2.774** (1.150) | 2.084* (0.412) | 0.00 | .988 |
| MTR (%), n = 44 | n = 18 | n = 7 | n = 8 | n = 5 | n = 6 | ||
| Pons | 40.1 (1.5) | 39.5 (0.5) | 38.4* (1.5) | 38.2 (2.6) | 39.1 (2.4) | −.11 | .600 |
| Thalamus** | 39.4 (0.9) | 39.5* (0.5) | 38.4* (1.5) | 38.2** (2.6) | 39.1** (2.4) | −.07 | .730 |
| Pallidum** | 37.1 (1.6) | 37.9** (1.6) | 37.6** (2.0) | 37.9** (0.7) | 37.6** (1.6) | .01 | .974 |
| Putamen** | 35.9 (1.5) | 32.1** (3.8) | 29.1** (5.6) | 28.7** (2.7) | 32.9** (1.7) | −.06 | .774 |
| Caudate** | 36.5 (2.2) | 33.1 (1.7) | 31.0* (2.6) | 32.3** (1.3) | 32.4** (2.5) | −.18 | .389 |
| Occipital lobe** | 39.0 (1.5) | 34.3** (4.0) | 32.8** (4.1) | 31.6** (2.1) | 32.8** (3.6) | .08 | .707 |
| ADC (10.5 mm2/s), n = 44 | n = 18 | n = 7 | n = 8 | n = 5 | n = 6 | ||
| Thalamus | 81.8 (4.7) | 79.4 (4.1) | 82.1 (5.1) | 86.4* (2.6) | 82.4 (7.1) | .31 | .121 |
| Occipital NAWM | 93.1 (15.7) | 91.9 (4.7) | 86.7 (8.0) | 100.2 (7.8) | 93.6 (8.6) | .18 | .378 |
Note:—1H-MRS indicates proton magnetic resonance spectroscopy; MTR, magnetization transfer ratio; ADC, apparent diffusion coefficient; HE, hepatic encephalopathy; mHE, minimal HE; mIns, myoinositol; Cr, creatine and phosphocreatine; NAA, N-acetylaspartate; Cho, choline-containing.
* Significantly different from control group (P < .05, Mann-Whitney U).
** Significantly different from control group (P < .01, Mann-Whitney U).