Average MD and FA values of ROIs from patients with RNMO and control subjects
| ROI | Average MD (×10−3 mm2 s−1) | Average FA | ||||
|---|---|---|---|---|---|---|
| RNMO | Controls | P* (95% CI) | RNMO | Controls | P* (95% CI) | |
| Medulla oblongata | 1.271 ± 0.111 | 1.111 ± 0.102 | <.001 | 0.266 ± 0.014 | 0.287 ± 0.026 | .005 |
| (1.212–1.330) | (1.057–1.165) | (0.084 to 0.237) | (0.259–0.274) | (0.275–0.300) | (−0.035 to −0.007) | |
| Cerebral peduncle | 1.007 ± 0.111 | 0.872 ± 0.053 | <.001 | 0.489 ± 0.035 | 0.535 ± 0.024 | <.001 |
| (0.948–1.066) | (0.843–0.900) | (0.072 to 0.198) | (0.471–0.508) | (0.522–0.548) | (−0.067 to −0.024) | |
| Internal capsule | 0.735 ± 0.010 | 0.718 ± 0.011 | <.001 | 0.661 ± 0.019 | 0.693 ± 0.022 | <.001 |
| (0.730–0.741) | (0.712–0.723) | (0.010 to 0.065) | (0.651–0.671) | (0.681–0.705) | (−0.047 to −0.017) | |
| Optic radiation | 0.876 ± 0.033 | 0.824 ± 0.031 | <.001 | 0.527 ± 0.039 | 0.585 ± 0.030 | <.001 |
| (0.859–0.894) | (0.808–0.840) | (−0.076 to −0.029) | (0.506–0.547) | (0.569–0.601) | (−0.083 to −0.033) | |
| Splenium of corpus callosum | 0.759 ± 0.034 | 0.726 ± 0.033 | .009 | 0.815 ± 0.034 | 0.817 ± 0.033 | .846 |
| (0.741–0.777) | (0.708–0.743) | (0.009 to 0.057) | (0.796–0.833) | (0.799–0834) | (−0.027 to 0.022) | |
| Genu of corpus callosum | 0.765 ± 0.049 | 0.731 ± 0.038 | .033 | 0.832 ± 0.033 | 0.829 ± 0.020 | .741 |
| (0.739–0.794) | (0.711–0.751) | (0.003 to 0.066) | (0.814–0.849) | (0.818–0.839) | (−0.016 to 0.023) | |
| Putamen | 0.729 ± 0.012 | 0.721 ± 0.011 | .068 | |||
| (0.722–0.735) | (0.715–0.727) | (−0.001 to 0.016) | ||||
| Thalamus | 0.775 ± 0.022 | 0.760 ± .025 | .066 | |||
| (0.763–0.786) | (0.746–0.772) | (−0.001 to 0.032) | ||||
| Frontal gray matter | 0.674 ± 0.042 | 0.634 ± 0.050 | .023 | |||
| (0.651–0.696) | (0.608–0.661) | (0.006 to 0.073) | ||||
| Parietal gray matter | 0.807 ± 0.014 | 0.779 ± 0.016 | <.001 | |||
| (0.800–0.814) | (0.771–0.788) | (0.017 to 0.038) | ||||
| Temporal gray matter | 0.838 ± 0.020 | 0.823 ± 0.011 | .016 | |||
| (0.827–0.849 | (0.818–0.829) | (0.003 to 0.026) | ||||
| Occipital gray matter | 0.780 ± 0.012 | 0.758 ± 0.016 | .007 | |||
| (0.770–0.790) | (0.746–0.770) | (0.006 to 0.036) | ||||
Note:—RNMO indicates relapsing neuromyelitis optica; MD, mean diffusivity; FA, fractional anisotropy; ROI, region of interest. Values are expressed as mean ± SD (95% confidence interval).
* Statistical analysis: Student t test for independent samples; P < .005 is considered significant.