Nonalcoholics: rank correlations of 1H-MRS, MTR, and ADC and grading of hepatic encephalopathy
| Nonalcoholics, Mean (±SD) | Correlation (Spearman-Rho) | ||||||
|---|---|---|---|---|---|---|---|
| Controls, Mean (±SD) | HE 0 | mHE | HE1 | HE2 | r | P | |
| 1H-MRS, n = 28 | n = 10 | n = 5 | n = 3 | n = 5 | n = 5 | ||
| Basal ganglia | |||||||
| mins/Cr** | 0.784 (0.570) | 0.320** (0.161) | 0.414 (0.154) | 0.250** (0.186) | 0.095** (0.097) | −.56 | .016 |
| NAA/Cr | 1.670 (0.252) | 1.742 (0.314) | 1.704 (0.057) | 1.447 (0.303) | 1.726 (0.292) | −.11 | .676 |
| Cho/Cr** | 0.267 (0.041) | 0.226 (0.032) | 0.261 (0.071) | 0.206* (0.039) | 0.190* (0.055) | −.31 | .206 |
| Glx/Cr* | 1.513 (0.556) | 1.823 (0.608) | 1.794 (0.316) | 2.133 (0.554) | 2.945** (0.392) | .62 | .006 |
| Occipital lobe | |||||||
| mins/Cr** | 0.823 (0.099) | 0.464 (0.416) | 0.481 (0.423) | 0.349** (0.201) | 0.063** (0.072) | −.53 | .024 |
| NAA/Cr* | 1.708 (0.175) | 1.760 (0.305) | 1.781 (0.257) | 1.939* (0.123) | 2.110** (0.076) | .63 | .005 |
| Cho/Cr | 0.258 (0.042) | 0.244 (0.046) | 0.259 (0.075) | 0.200* (0.036) | 0.228 (0.030) | −.21 | .397 |
| Glx/Cr** | 1.413 (0.489) | 1.998 (0.594) | 1.774 (0.484) | 2.458** (0.590) | 3.035** (0.887) | .52 | .027 |
| MTR (%), n = 37 | n = 18 | n = 5 | n = 3 | n = 6 | n = 5 | ||
| Pons | 40.1 (1.5) | 40.1 (3.2) | 38.5 (0.9) | 40.2 (2.9) | 37.9 (4.8) | −.17 | .480 |
| Thalamus** | 39.4 (0.9) | 38.8 (1.3) | 38.9 (1.4) | 37.1** (2.5) | 35.6** (1.3) | −.64 | .003 |
| Pallidum** | 37.1 (1.6) | 34.4 (6.0) | 32.5 (6.2) | 28.7** (6.0) | 25.7** (2.5) | −.58 | .010 |
| Putamen** | 35.9 (1.5) | 34.5 (3.5) | 33.1 (3.1) | 30.3** (3.7) | 28.9** (1.7) | −.61 | .006 |
| Caudate** | 36.5 (2.2) | 35.3 (3.9) | 31.2* (3.3) | 31.1** (4.4) | 30.73** (1.8) | −.44 | .062 |
| Occipital lobe** | 39.0 (1.5) | 37.2 (2.3) | 35.3 (3.4) | 33.2* (4.5) | 30.76** (2.4) | −.67 | .002 |
| ADC (10.5 mm2 s), n = 37 | n = 18 | n = 5 | n = 3 | n = 6 | n = 5 | ||
| Thalamus | 81.8 (4.7) | 78.8 (2.3) | 84.1 (2.1) | 82.81 (4.6) | 83.8 (3.8) | .42 | .070 |
| Occipital NAWM | 93.1 (15.7) | 86.1 (4.0) | 86.7 (6.9) | 94.6 (12.0) | 104.0 (20.3) | .48 | .035 |
Note:—1H-MRS indicates proton magnetic resonance spectroscopy; MTR, magnetization transfer ratio; ADC, apparent diffusion coefficient; HE, hepatic encephalopathy; mHE, minimal HE; mIns, myoinositol; Cr, creatine and phosphocreatine; NAA, N-acetylaspartate; Cho, choline-containing.
Bold figures indicate significance (P < .05).
* Significantly different from control group (P < .05, Mann-Whitney U).
** Significantly different from control group (P < .01, Mann-Whitney U).