TABLE 1:

Summary of previous cases of tumors in the central nervous system associated with Klinefelter syndrome

Patient No./Age (y)/SexSeriesTumor LocationSurgeryHistologic Diagnosis
1/16/MRubenstein, 19729Pineal regionNot describedGerminoma
2/20/MAhagon et al, 198310Suprasellar regionBiopsyGerminoma
3/12/MEllis et al, 198611Posterior hypothalamus, left frontal lobeRadical excisionGerminoma
4/15/MArens et al, 198812Pineal regionBiopsyGerminoma
5/40/MLiang et al, 199013Right frontoparietal regionPartial excisionNon-Hodgkin’s lymphoma
6/19/MHashimoto, et al, 199214Medulla oblongataBiopsyGerminoma
7/12/MPrall et al, 199515Pineal regionSubtotal resectionMalignant mixed germ cell tumor
8/13/MWysocka et al, 199616CerebellumTotal resectionPilocytic astrocytoma
9/19/MKaido et al, 20032Hypothalamus–temporal regionPartial removalGerminoma
10/29/MGanslandt et al, 20006Spinal cord (T12–L4)Partial resectionGerminoma
11/35/MOur patient 1Spinal cord (T6–T7), hypothalamic regionTotal resectionGerminoma
12/27/MOur patient 2Spinal cord (T7–T9), cerebellum, intraventricular regionPartial resectionGerminoma