Clinical and MR imaging findings in patients with ALS
| Patient No. | Age (y) | Sex | Duration Before MRI (y) | Dementia (HDS-R) | Bulbar Symptoms | Upper Motor Neuron Symptoms | Lower Motor Neuron Symptoms, Upper Extremities | Lower Motor Neuron Symptoms, Lower Extremities | Atrophy Frontotemporal Lobes* | HI Anterior Temporal White Matter | HI Bilateral Precentral White Matter | HI Bilateral Corticospinal Tracts | HI Bilateral Precentral Cortices | Small Infarction or Unidentified Bright Objects |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 58 | M | 1 | +, 17/30 | + | − | + | + | 2, T, bilateral | +, bilateral | − | − | + | − |
| 2 | 65 | M | 6 | +, 14/30 | + | − | + | + | 3, T, bilateral | +, bilateral | + | − | − | + |
| 3 | 71 | F | 2 | +, 9/30 | + | − | + | + | 2, Fr, bilateral | +, bilateral | − | − | − | + |
| Subtotal | 64.7 ± 6.5 | 3.0 ± 2.6 | 100% | 2.33 | 100% | 33.3% | 0% | 33.3% | 66.7% | |||||
| 4 | 46 | M | 1 | − | + | + | + | + | 1 | − | − | − | − | − |
| 5 | 50 | F | 6 | − | + | + | + | + | 1 | − | − | − | + | − |
| 6 | 54 | F | 6 | − | − | + | + | + | 1 | − | − | − | − | − |
| 7 | 55 | F | 2 | − | + | + | + | + | 2, Fr, bilateral | − | + | + | + | − |
| 8 | 57 | M | 1 | − | + | + | + | + | 1 | − | − | − | − | + |
| 9 | 57 | M | 3 | − | + | − | − | − | 1 | − | − | − | − | + |
| 10 | 58 | F | 1 | − | + | + | + | + | 1 | − | + | + | + | + |
| 11 | 60 | F | 1 | − | + | + | + | − | 1 | − | − | + | + | − |
| 12 | 62 | F | 0 | − | + | + | + | − | 1 | − | + | + | + | + |
| 13 | 62 | F | 2 | − | + | + | + | + | 2, Fr, bilateral | − | − | + | + | + |
| 14 | 62 | M | 4 | − | + | + | + | + | 2, T, bilateral | − | − | − | + | + |
| 15 | 62 | M | 6 | − | + | + | + | − | 1 | − | − | − | − | + |
| 16 | 65 | M | 7 | − | + | + | + | − | 2, T, bilateral | − | − | − | − | − |
| 17 | 67 | M | 2 | − | − | + | − | + | 1 | − | + | − | + | − |
| 18 | 69 | M | 8 | − | + | + | + | + | 1 | − | − | − | + | + |
| 19 | 70 | F | 2 | − | + | + | + | + | 1 | − | + | − | + | + |
| 20 | 71 | M | 5 | − | + | + | + | + | 2, T, bilateral | − | + | − | + | + |
| 21 | 74 | F | 1 | − | + | + | + | + | 1 | − | + | − | − | + |
| 22 | 74 | M | 2 | − | − | − | + | + | 2, Fr, bilateral | − | − | − | − | + |
| 23 | 74 | M | 4 | − | + | + | + | + | 1 | − | + | + | + | + |
| 24 | 74 | M | 4 | − | + | − | + | + | 1 | − | + | − | + | + |
| Subtotal | 63.0 ± 8.3 | 3.2 ± 2.3 | 0% | 1.33 | 0% | 42.9% | 28.6% | 61.9% | 66.7% | |||||
| Total | 63.2 ± 8.0 | 3.2 ± 2.3 | 12.5% | 1.46 | 12.5% | 41.7% | 37.5% | 58.3% | 66.7% |
Note:—HI indicates hyperintensity; Fr, frontal dominance; T, temporal dominance; +, present; −, absent.
* 3 indicates severe; 2, moderate; 1, mild or absent.