Abciximab | Tirofiban | Eptifibatide | |
---|---|---|---|
Manufacturer | Eli Lilly | Merck | COR Therapeutics |
Molecule size, datons | 50,000 | 800 | 500 |
Receptor affinity (KD) | High (5 nmol/L) | Low (15 nmol/L) | Low (120 nmol/L) |
Plasma high-life, h | 0.2 | 1.5–2 | 2–4 |
Biologic half-life, h | 12–24 | 1.5–2 | 2–4 |
Excretion | Renal | Renal/hepatic | Renal |
Method of reversal | Platelet transfusion | Fresh-frozen plasma, cryprecipitate, platelet transfusion | Fresh-frozen plasma, cryprecipitate, platelet transfusion |