Table 5:

Comparison of the glycoprotein IIb/IIIa antagonists

AbciximabTirofibanEptifibatide
ManufacturerEli LillyMerckCOR Therapeutics
Molecule size, datons50,000800500
Receptor affinity (KD)High (5 nmol/L)Low (15 nmol/L)Low (120 nmol/L)
Plasma high-life, h0.21.5–22–4
Biologic half-life, h12–241.5–22–4
ExcretionRenalRenal/hepaticRenal
Method of reversalPlatelet transfusionFresh-frozen plasma, cryprecipitate, platelet transfusionFresh-frozen plasma, cryprecipitate, platelet transfusion