Table 1:

Clinical features of 12 patients with acute necrotizing encephalopathy of childhood

Patient No./Age/Sex	Clinical Features	Positive Viral Study	Outcome	HUI:1 Outcome Category
1/1 y 4 mo/M	Fever, conscious disturbance, seizure	Influenza B	Spasticity with decerebrate posture	3
2/3 y 3 mo/M	Fever, conscious disturbance, seizure	Mycoplasma	Spasticity	2
3/12 y/F	Fever, conscious disturbance, decerebrate posture, spasticity, urine and stool incontinence	Influenza B, mycoplasma (possible)	Spasticity, urine and stool incontinence	2
4/7 mo/M	Conscious disturbance	N/A	Fully recovered	1
5/10 y/M	Fever, conscious disturbance, seizure	Influenza A	Bilateral hand tremor; left-sided dystonia	2
6/1 y/M	Fever, lower extremity rigidity	N/A	Fully recovered	1
7/3 y 5 mo/M	Fever, conscious disturbance, decerebrate posture	Influenza B	Spasticity, speech disorder	2
8/2 mo/M	Fever, conscious disturbance, seizure, motor weakness with cogwheel rigidity	HHV-6	Speech disorder; full motor recovery	2
9/6 y/F	Fever, skin rash, conscious disturbance, seizure, lower extremity paralysis, speech disability	Adenovirus	Neurogenic bladder, lower extremity weakness	2
10/2 y/M	Fever, coma, seizure	N/A	Lower extremity weakness with rigidity	2
11/2 y 6 mo/F	Fever, conscious disturbance, seizure, lower extremity paralysis	Negative	Lower extremity weakness	2
12/2 y 4 mo/F	Fever, conscious disturbance 1 mo, vomiting, seizure	Enterovirus	Conscious disturbance, diplegia, spasticity	3

Note:—NUI:1 indicates Health Utilities Index Mark 1; HHV-6, human herpes virus 6; N/A, not available.