Clinicopathological details of 82 patients with ARL in the HAART eraa
| Clinical Characteristic | Number (%) |
|---|---|
| Sex | |
| Male | 74 (90) |
| Female | 8 (10) |
| Prior AIDS-defining illness | |
| No | 68 (83) |
| Yes | 14 (17) |
| On antiretrovirals prior to ARL diagnosis | |
| No | 31 (38) |
| Yes | 51 (62) |
| HIV-1 RNA viral load <50 copies/mL at the time of diagnosisb | |
| No | 62 (76) |
| Yes | 20 (28) |
| International Prognostic Index risk groupc | |
| High | 21 (26) |
| High/intermediate | 22 (28) |
| Low | 19 (24) |
| Low/intermediate | 18 (22) |
| ECOG performance status | |
| 0 | 5 (6) |
| 1 | 39 (48) |
| 2 | 22 (27) |
| 3 | 9 (11) |
| 4 | 7 (8) |
| Histology | |
| Burkitt | 11 (13) |
| DLBCL | 65 (79) |
| Other | 5 (8) |
| Meningeal enhancement on CT | |
| No | 79 (97) |
| Yes | 3 (3) |
| Parenchymal lesion on CT brain | |
| No | 75 (91) |
| Yes | 7 (9) |
| Raised CSF protein | |
| No | 36 (44) |
| Yes | 43 (46) |
| Meningeal disease at diagnosis | |
| No | 65 (79) |
| Yes | 17 (21) |
Note:—DLBLC indicates diffuse large B-cell lymphoma; RNA, ribonucleic acid.
a CD4 subset analysis was performed using whole blood stained with murine antihuman monoclonal antibodies to CD4 (T helper cells, TetraOne; Beckman Coulter, High Wycombe, UK) and was evaluated on an Epics XL-MCL (Beckman Coulter) multiparametric 4-color flow cytometer. There were no missing data.
b Plasma viral loads (Quantiplex HIV RNA 3.0; Chiron, Halstead, UK) were recorded since 1998 with a lower limit of detection of 50 copies/mL.
c The International Prognostic Index was defined according to well-known established criteria.12