Patients (before Therapy) | Control (Newborn, 5–7 days) | P Value | Patients (after therapy) | Control (after 8 weeks) | P Value | |
---|---|---|---|---|---|---|
FWM | 0.88 ± 0.27 | 1.06 ± 0.16 | N.S. | 1.28 ± 0.35 | 1.43 ± 0.17 | NS |
NAA/Cr | ||||||
FWM | 2.12 ± 0.77 | 2.02 ± 0.46 | N.S. | 1.50 ± 0.33 | 1.73 ± 0.20 | NS |
Cho/Cr | ||||||
Thalamus | 1.09 ± 0.24 | 1.29 ± 0.13 | <0.05 | 1.45 ± 0.17 | 1.38 ± 0.21 | NS |
NAA/Cr | ||||||
Thalamus | 1.78 ± 0.35 | 1.70 ± 0.18 | NS | 1.44 ± 0.15 | 1.37 ± 0.26 | NS |
Cho/Cr | ||||||
PWM | 1.04 ± 0.23 | 1.38 ± 0.17 | <0.05 | 1.39 ± 0.25 | 1.52 ± 0.29 | NS |
NAA/Cr | ||||||
PWM | 1.91 ± 0.39 | 1.89 ± 0.42 | NS | 1.33 ± 0.25 | 1.57 ± 0.21 | NS |
Cho/Cr |
Note:—FWM indicates frontal while matter; NAA, N-acetylaspartate; Cr, creatine; Cho, choline; PWM, parietal white matter; NS, nonsignificant (P > .05).