Table 3:

Clinical features of patients with infection, sepsis, and shock

Pt #	Age	Sex	Major Clinical Problem and Infection	Cultured Organism		S/S	MOD	Delay	PRES Neurotoxicity	BP Base	BP Tox	MAP Tox
Pt #	Age	Sex	Major Clinical Problem and Infection	Organ/Tissue	Blood	S/S	MOD	Delay	PRES Neurotoxicity	BP Base	BP Tox	MAP Tox
Group 1
1	39	M	Pneumonia with bronchial obstruction, decubitus ulcer	S. aureus	Staph coag neg	Y		13D	Headache Seizure	122/61	118/70	86
2	73	F	Gastric surgery, pneumonia, aspiration	Pseudomonas	P. aeruginosa	Y	CR	6D	Altered MS	157/77	128/80	78
3	59	F	Bowel perforation, abscess, sepsis, MOD, antiphospholipid syndrome	Pseudomonas	Staph coag neg	Y	CP	13D	Altered MS	143/79	150/56	87
				Staph coag neg
4	56	F	Thigh abscess	Klebsiella		Y	CP	27D	Seizure	156/68	164/75	104
				Enterococcus F1			LR
5	24	F	CML in blast crisis, isolated bacteremia, sepsis, chemotherapy		Enterobacter	Y	PL	20D (15D)	Slurred speech	122/82	125/85	98
							R		Ataxia
									Seizure
6	20	M	ALL, chemotherapy, skin infection	Staph coag neg	1. Diphtheroids	–	CP	7D	Seizure	120/70	150/88	106
					2. Staph coag neg		LR
7	68	F	Necrotic pancreatitis, pancreatic abscess	Staph coag neg	Staph coag neg	Y	CP	7D	Altered MS	141/67	168/68	101
				Acinetobacter			L
8	55	F	Liver metastatis, open hepatic chemotherapy infusion, pneumonia	S. aureus	1. S. pneumoniae	Y	CP	3D	Altered MS	115/70	150/82	104
					2. Staph coag neg		LR
9	66	F	Toe infection and abscess, diabetic	S. aureus			R	9D	Seizure	132/52	160/60	93
				Staph coag neg
				Yeast
10	79	F	Lap-cholecystectomy; severe abdominal hemorrhage			Y	CP LR	7D	Altered MS	138/73	137/74	95
Group 2
11	61	F	Postoperative wound infection	S. aureus	S. aureus			11D	Headache	145/65	210/102	138
									Vision loss
12	24	F	Isolated bacteremia 2 mo post Tx removal		S. viridans		R	0D	Headache Seizure	125/90	170/126	140
13	22	M	Original sickle cell crisis w/pneumonia-bacteremia, new sickle cell crisis w/heavy rectal colonization	N/A	Staph coag neg		CR	2M	Sickle crisis Seizure	122/80	200/100	133
				Enterococcus F2
14	37	M	Chronic septic arthritis, shoulder abscess	S. aureus	N/A		CR	?	Headache Vision change	175/85	184/111	135
									Seizure
15	26	F	Crohn disease, bowel perforation, abdominal abscess	Enterococcus F1	Staph coag neg	Y	CP	7D	Seizure	115/65	182/100	126
				Enterococcus F2
				E coli
16	51	F	Breast carcinoma, auto-BMT, pneumonia	Pseudomonas	1. Micrococcus	Y	C p L	9D	Seizures	121/74	164/100	123
				Klebsiella	2. Enterococcus
				Staph coag neg	3. Staph coag neg
17	55	M	Foot infection, diabetic	N/A on antibiotics			C	0D	Headache Vision change	191/88	215/115	148
18	57	F	Post gastric stapling, acute UTI	Enterococcus F1	Staph coag neg			2D	Altered MS Seizure	136/70	203/93	129
19	54	F	Pneumonia, severe; intubated	N/A outside hosp				9D	Vision change Altered MS	112/85	200/100	133
20	81	F	Axillary abscess, chemotherapy	S. aureus	1. S. aureus	Y	CL	30D	Slurred speech Altered MS	130/52	203/110	141
					2. Staph coag neg				Seizure
21	37	F	Necrotizing pancreatitis, pneumonia	N/A outside hosp				7D	Headache Seizure	162/92	220/126	157
22	56	F	Sickle cell crisis, pneumonia	S. viridans			R	4D	Altered MS Seizure	150/84	170/110	130
23	24	F	Alcohol intoxication, shock, bowel perforation	N/A on antibiotics		Y	CP LR	6D	Seizure	140/90	203/113	143
24	38	F	Peritonitis, PD, renal insufficiency	Pseudomonas	Pseudomonas			14D	Altered MS	145/94	210/110	143
25	19	F	Dialysis catheter hemorrhage			Y	CP R	15D	Headache Vision change	149/86	207/106	140
									Seizure

Note:—S/S indicates clinically hemorrhagic shock or sepsis, severe sepsis, or septic shock before developing PRES; Y, yes; MOD; multiorgan dysfunction developed coincident with PRES; C, coagulation, drop in platelet count; P, pulmonary dysfunction-edema, intubation; L, hepatic dysfunction, rising and elevated bilirubin; R, renal dysfunction, rising and elevated creatinine; Delay, closest time from recognized infection/bacteremia/shock to onset of neurotoxicity and PRES; MS, mental status; BP, blood pressure (mm Hg); base, baseline; tox, at toxicity; MAP, mean arterial pressure; N/A, not available; Tx, transplant; PD, peritoneal dialysis; UTI, urinary tract infection; PRES, posterior reversible encephalopathy syndrome. CML, chronic myelogenous leukemia; ALL, acute lymphoblastic leukemia; auto-BMT, auto-bone marrow transplant; S aureus, Staphylococcus aureus; Staph coag neg, coagulase-negative Staphylococci; E coli, Escherichia coli; S viridans, Streptococci viridans; S pneumoniae, Streptococci pneumoniae. Multiple organisms listed together correspond to mixed flora infections. Numbered blood culture organisms correspond to separate blood culture results with different organisms in the PRES time frame. F1, faecalis; F2, faecium. In patient 5, initial neurotoxicity began 15 days after sepsis/7 days after chemotherapy. Initial imaging negative (16 days), repeat imaging demonstrating PRESS (20 days).