Longitudinal structural MRI studies on at-risk subjects
| MRI Study | N | Decline | Baseline Clinical Characteristics* | FU | ROI | Mag | |||
|---|---|---|---|---|---|---|---|---|---|
| Age (yr) | M | MMSE | Ed | ||||||
| Galton et al, 200524 | 29/11 | ND to AD | 63.7 (9.9) | 48.2 | 27.4 (2.4) | NA | 24.2 | HIP | NA |
| Convit et al, 200025 | 46/14 | NL and MCI to AD† | 74.0 (7.0) | 47.8 | 27.8 (2.4) | 14.8 (3.0) | 38.4 | MTL | 1.5 |
| Devanand et al, 200726 | 114/31 | MCI to AD | 66.8 (9.8) | 43.9 | 27.5 (2.2) | 15.2 (4.2) | 60 | HIP ENT | 1.5 |
| Geroldi et al, 200627 | 52/11 | MCI to D | 70 (6) | 44.0 | 27.2 (1.7) | 7.2 (4.2) | 15.4 | MTL | NA |
| Visser et al, 199928 | 13/9 | MD to AD | 78.8 (4.8) | 30.0 | 22.6 (2.0) | 7.7 (2.1) | 36 | MTL | 0.6 |
| Korf et al, 200429 | 75/37 | MCI to D | 62.9 (9.2) | 40.0 | 26.9 (2.9) | 10.2 (3.0) | 34 | MTL | 1.5 |
| Visser et al, 200230 | 26/7 | MCI to AD | 64.9 (9.5) | 58.1 | 27.7 (1.8) | 10.7 (3.2) | 22.8 | HIP | 1.5 |
| Dickerson et al, 200131 | 23/12 | MCI to AD | 68.6 (8.6) | 67.9 | 27.0 (2.2) | 15.2 (3.1) | 15 | ENT | 1.5 |
| Teipel et al, 200732 | 22/7 | aMCI to AD | 69.7 (8.5) | 45.8 | 27.0 (1.8) | NA | 27.0 | MTL AA | 1.5 |
| Killiany et al, 200033 | 79/19 | QA to AD | 72 | 40.0 | 29.1 | NA | 36 | STS, AC | NA |
Note:—MRI indicates MR imaging; AA, neocortical association areas; AC, anterior cingulate; ENT, entorhinal cortex; HIP, hippocampus; Mag, magnet strength in Teslas; MD, minimal dementia; MTL, medial temporal lobe; ND, non-demented; NL, normal controls; STS, superior temporal sulcus.
* Each cell was listed as mean value (SD).
† Including 12 MCI and 2 NL.