Brain MR imaging measures in normal control subjects and multiple sclerosis patients, according to disease type
| Variable | NC (n= 19), Mean (SD) | MS (n= 66), Mean (SD) | CIS (n= 11), Mean (SD) | RR (n= 34), Mean (SD) | SP (n= 14), Mean (SD) | PP (n= 7), Mean (SD) |
|---|---|---|---|---|---|---|
| BPF | 0.845 (0.006) | 0.827 (0.02) | 0.834 (0.01) | 0.832 (0.01) | 0.815 (0.02) | 0.815 (0.009) |
| MPD, × 10−6 mm2/s | 1130.1 (65.8) | 1204.3 (89.2) | 1143.4 (59.1) | 1222.8 (100.4) | 1196.3 (71) | 1222.9 (61) |
| T2-LV, mL | NA | 11 (12.6) | 5.1 (6.5) | 12.1 (14.4) | 18.3 (13.5) | 6.9 (7.7) |
| T1-LV, mL | NA | 1.7 (3.2) | 0.5 (0.7) | 1.2 (1.7) | 3.2 (5.4) | 1.2 (1.5) |
Note:—NC indicates normal control subjects; MS, multiple sclerosis; RR, relapsing-remitting; SP, secondary-progressive; PP, primary-progressive; CIS, clinically isolated syndrome; BPF, brain parenchyma fraction; MPD, mean parenchyma diffusivity; LV, lesion volume; NA, nonapplicable.