Multivariate analysis of specific prognostic factors
| Prognostic Factor | Hazard Ratio* (95% CI) | P Value |
|---|---|---|
| Age ≥50 years | NA | .814 |
| Sex: male | 2.632 (1.153–6.010) | .021 |
| Histologic diagnosis of GBM | 9.707 (3.163–29.788) | <.001 |
| Neurologic function: home or hospital† | NA | .435 |
| Abnormal mental status | NA | .228 |
| KPS score ≤ 80 | NA | .150 |
| Extent of surgery: biopsy | 2.692 (1.196–6.061) | .016 |
| Tumor enhancement: present | NA | .726 |
| rCBV > 2.3 | 4.739 (1.950–11.518) | <.001 |
Note:—NA indicates not applicable; GBM, glioblastoma multiforme; KPS, Karnofsky performance scale; rCBV, relative cerebral blood volume.
* Hazard ratio was not calculated when P ≥ .05.
† Neurologic function is limited so that the patient is either confined to the home or hospitalized.