Main metabolite concentration ratios in the cervical spinal cord of healthy volunteers and patients with RRMS
| tNAA:Cr | tNAA:Cho | Cho:Cr | mIns:Cr | |
|---|---|---|---|---|
| Healthy cervical spinal cord | ||||
| Mean | 1.4 ± 0.3 | 3.1 ± 0.8 | 0.5 ± 0.1 | 1.7 ± 0.2 |
| CV (%) | 23 | 26 | 10 | 13 |
| RRMS cervical spinal cord | ||||
| Mean | 1.1 ± 0.3 | 2.0 ± 0.7 | 0.6 ± 0.1 | 2.0 ± 0.4 |
| CV (%) | 32 | 35 | 19 | 21 |
| Pvalue | .04 | .002 | .003 | .004 |
Note:—RRMS indicates relapsing-remitting MS; tNAA, total N-acetylaspartate; Cr, creatine; Cho, choline; mIns; myo-inositol; CV, coefficient of variation.