Table 1:

Characteristics of included studiesa

ArticleYearJournalStudy TypertPA Dose/NINDSSite of OcclusionRecan. Assessment ToolRecan. TimesNo. of Patients With Recan.Total No. of Relevant Patients
Noncontrast Studiesb
    Alexandrov et al2004Stroke Prospective cohortYes <180 minM1, M2TCD2 h (Post-rtPA)73120
    Daffertshofer et al2005StrokeNRCTYes <360 minICA, M1, M2, M3MRA24 h1026
    Derex at al2004NeuroradiologyProspective cohortNo <360 minICA, M1, M2, ACAMRA24 h2847
    Eggers at al2003Ann NeurolRCTYes <180 minM1, M2TCD1 h (Post-rtPA)825
    Gerriets et al2002StrokeRCT (substudy of DIAS 1)Yes <360 minICA, M1, M2TCD24 h811
    Kwon et al2004Arch NeurolRetrospective cohortYes <360 minICA, MCAMRA72 h1420
    Molina et al2001StrokeCase controlYes <180 minM1, M2TCD48 h2224
    Neumann-Haefelin et al 2004StrokeRetrospective cohortNS <360 minM1MRA24 h1852
    Rubiera et al2006StrokeProspective cohortYes <360 minICA, M1, M2TCD2 h (Post-rtPA)141219
    Savitz et al2005StrokeRetrospective cohortYes <360 minICA, MCAMRA72 h2737
    Sekoranja et al2006StrokeProspective cohortYes <180 minICA, MCATCD30 min (Post-rtPA)1733
    Yasaka et al1998NeurologyRCTNo 210 ± 36 minMCA; origin, trunk, distalTCD24 h88
Contrast Contrast studiesb
    Muir et al2005JNNPProspective cohortYes <200 minM1, M2CTA, TCD, DSA48 h912
    Murphy et al2006StrokeProspective cohortNS <420 minMCA syndromeCTA24 h47
    Wintermark et al2006StrokeProspective cohortNo <420 minLarge-artery occlusionMRA2–7 d2841
    von Kummer et al1995StrokeProspective cohortNo <360 minICA, M1, M2DSAImmediately post-rtPA1961
    Sasaki et al1996AJNRProspective cohortNo <480 minM1, M2DSA24 h13
    Mori et al1992NeurologyRCTNo <360 minICA, M1, M2, AMDSAImmediately post-rtPA919
  • Note:—Recan. indicates recanalization, JNNP, J Neurol Neurosurg Psychiatry; RCT, randomized controlled trial; NRCT, non-randomized controlled trial; CTA, CT angiography; DSA, digital subtraction angiography; MRA, MR angiography; TCD, transcranial Doppler sonography; ICA, internal carotid artery; ACA, anterior cerebral artery; MCA, middle cerebral artery; M1, M1 branch of the MCA; M2, M2 branch of the MCA; M3, M3 branch of the MCA; AM, A2 branch of the ACA; NS, not specified; rtPA, recombinant tissue plasminogen activator; DIAS I, Desmoteplase in Acute Ishemic Stroke Trial; NINDS, National Institute of Neurological Disorders and Stroke.

  • a Included are data indicating whether rtPA was administered as per the protocol used in the NINDS trial.24

  • b All studies are listed in on-line Fig 1.