Age (y)/Sex | 13/F | 14/F | 15/M | 12/F |
Symptoms | 6 wk sore throat, odynophagia, voice change, neck mass | 4 mos hoarseness, 1 mo odynophagia, dysphagia | Nasal mass | 3 wk URT symptoms and nasal mass |
Tumor location | Epiglottis | Epiglottis and glottis | Sinonasal | Sinonasal |
CT scan results | 3-cm heterogeneously enhancing epiglottic mass necrotic, level II LN | 3-cm heterogeneously enhancing submucosal mass | 3 cm lobulated, moderately enhancing mass left nasal cavity, bony remodeling | 5 × 7-cm moderately enhancing mass, nasal cavity. Bony destruction sinuses, skull base |
MR imaging results | | Isointense with cortex on FSEIR | Isointense with cortex on FSEIR | Isointense with cortex on FSEIR |
Surgery | Modified radical neck dissection | Biopsy | Midface degloving; left Caldwell-Luc | Biopsy |
Histopathology | Undifferentiated carcinoma | Well-differentiated squamous carcinoma | Poorly differentiated squamous carcinoma | Poorly differentiated squamous carcinoma |
Cytogenetics | 47,XX, +8, t(15;19)(q13;p13.1). | | 46,XY, +der(1)t(1;5)(p12;q11.1), −5,del(22)(q11q13) | T(15;19) |
EBV | Negative | | Negative | Negative |
Chemotherapy | Cisplatin, 5-fluorouracil, docetaxel, methotrexate, vinblastine | Cisplatin | VCR/Cytoxan, Adriamycin, etoposide, carboplatin | Carboplatin |
Radiation | 69 Gy to supraglottis | 70.2 Gy to larynx | | 64.4 Gy to nasopharynx |
| 54.0 Gy to neck nodes | 52.2 Gy to neck nodes | | 50.4 Gy to neck nodes |
Clinical course | Disseminated disease. Death 10 mos after diagnosis | Alive at 8 y f/u. Laryngeal scarring, stenosis. Tracheostomy | Disease-free at 8 y f/u | Disseminated disease. Death 3 mos VBIO, VCR after diagnosis |