Distribution of contrast enhancement in the AES in relation to histopathologic findings in 42 eyes with retinoblastomaa
| Variable | Normal (n = 13) | Moderate (n = 15) | Strong (n = 14) | P Value |
|---|---|---|---|---|
| Tumor location | .88 | |||
| Anterior to equator | 2 (15) | 1 (7) | 1 (7) | |
| Posterior to equator | 8 (62) | 8 (53) | 8 (57) | |
| Combination | 3 (23) | 6 (40) | 5 (36) | |
| Necrosis | .56 | |||
| Mean ± SD | 24.6 ± 20.0 | 34.0 ± 21.2 | 20.7 ± 11.9 | |
| Range | 5–60 | 5–70 | 10–50 | |
| Choroidal inflammation | .02 | |||
| Yes | 5 (39) | 4 (27) | 0 (0) | |
| No | 8 (62) | 11 (73) | 14 (100) | |
| Choroidal invasion | .17 | |||
| Massive | 0 (0) | 0 (0) | 0 (0) | |
| Minimal | 4 (31) | 4 (27) | 1 (7) | |
| No | 9 (69) | 11 (73) | 13 (93) | |
| Scleral invasion | 1.00 | |||
| Yes | 0 (0) | 0 (0) | 0 (0) | |
| No | 13 (100) | 15 (100) | 14 (100) | |
| AES | 1.00 | |||
| Yes | 0 (0) | 1 (7) | 0 (0) | |
| No | 13 (100) | 14 (93) | 14 (100) | |
| Optic nerve invasion | <.0001 | |||
| Postlaminar | 0 (0) | 1 (7) | 2 (14) | |
| Prelaminar | 2 (15) | 5 (33) | 10 (71) | |
| No | 11 (85) | 9 (60) | 2 (14) | |
| IA | .06 | |||
| Stage 3 | 0 (0) | 0 (0) | 1 (7) | |
| Stage 2 | 0 (0) | 3 (20) | 1 (7) | |
| Stage 1 | 1 (8) | 4 (27) | 4 (29) | |
| Stage 0 | 12 (92) | 8 (53) | 8 (57) | |
| Iris vessel count/5 HPF | .18 | |||
| Mean ± SD | 75.8 ± 11.9 | 83.9 ± 14.6 | 83.2 ± 14.6 | |
| Range | 56–93 | 47–102 | 66–124 | |
| Iris surface-vessel count/5 HPF | <.0001b | |||
| Mean ± SD | 3.7 ± 2.8 | 9.5 ± 6.6 | 12.8 ± 9.5 | |
| Range | 0–9 | 1–26 | 1–32 |
a Unless otherwise indicated, data are the number of eyes, and numbers in parentheses are percentages.
b Square-root transformed for statistical analysis because of skewed distribution.