Table 4:

Quantitative MR imaging parameters by tissue type and clinical groupa

NAWMDAWMLesionsSignificant Pair-wise Comparisons between Tissue TypesSignificant Comparisons between Disease Types
ADC (μm2 s−1)PP805 ± 53842 ± 481042 ± 216Lesions vs NAWM, P < .05
SP798 ± 40903 ± 771201 ± 131DAWM vs NAWM, P < .001; DAWM vs lesions, P < .001; lesions vs NAWM, P < .001
FAPP0.383 ± 0.0580.350 ± 0.0470.318 ± 0.110DAWM vs NAWM P < .01; DAWM vs lesions, P < .05; lesions vs NAWM, P < .001
SP0.365 ± 0.0330.322 ± 0.0300.242 ± 0.054DAWM vs NAWM, P < .001; DAWM vs lesions, P < .001; lesions vs NAWM, P < .001
MTR (%)PP32.9 ± 0.631.1 ± 1.028.2 ± 3.6DAWM vs NAWM, P < .01; lesions vs NAWM, P < .05DAWM SP vs PP, P < .001; lesions SP vs PP, P < .01
SP32.8 ± 1.228.8 ± 0.821.3 ± 3.3DAWM vs NAWM, P < .001; DAWM vs lesions, P < .001; lesions vs NAWM, P < .001
T1 (ms)PP759 ± 27823 ± 381040 ± 185DAWM vs NAWM, P < .05DAWM SP vs PP, P < .001; lesions SP vs PP, P < .05
SP815 ± 47958 ± 671419 ± 298DAWM vs NAWM, P < .001; DAWM vs lesions, P < .001; lesions vs NAWM, P < .001
  • a Means and SDs of ADC, FA, MTR, and T1 in NAWM, DAWM, and lesions by clinical group (PP or SPMS). Bonferroni-corrected P values derived from general linear mixed model analysis are indicated for statistically significant pair-wise differences between tissue types and disease types. Details of statistical analyses are provided in the text.